Pregnancies Tied to Breast Cancer Odds for High-Risk Women Pregnancies Tied to Breast Cancer Odds for High-Risk Women
Having more than one pregnancy has long been linked to lower odds of breast cancer, and a new study suggests that may hold true even for some women with genetic mutations that put them at high risk for these malignancies.Reuters Health Information
Condition: Breast Cancer Female Intervention: Other: questionnaires Sponsors: Institut Curie; seintinelles network Recruiting
by Lina Ding, Lauren B. Shunkwiler, Nicholas W. Harper, Yang Zhao, Kunihiko Hinohara, Sung Jin Huh, Muhammad B. Ekram, Jan Guz, Michael J. Kern, Alexander Awgulewitsch, James D. Shull, Bart M. G. Smits, Kornelia Polyak Mammary epithelial progenitors are the normal cell-of-origin of breast cancer. We previously defined a population of p27+ quiescent hormone-responsive progenitor cells in the normal human breast whose frequency associates with breast cancer risk. Here, we describe that deletion of theCdkn1b gene encoding the p27 cyclin-dependent kinase inhibitor in the estrogen-induced mammary tumor-susceptible ACI rat stra...
(Reuters Health) - Having more than one pregnancy has long been linked to lower odds of breast cancer, and a new study suggests that may hold true even for some women with genetic mutations that put them at high risk for these malignancies.
Journal of Women's Health, Ahead of Print.
tticrew There are concerns about the accuracy of the health information provided by alcohol industry (AI)-funded organisations and about their independence. We conducted a content analysis of the health information disseminated by AI-funded organisations through Twitter, compared with non-AI-funded charities, to assess whether their messages align with industry and/or public health objectives. We compared all tweets from 2016 from Drinkaware (UK); Drinkaware.ie (Ireland); and DrinkWise (Australia), to non-AI-funded charities Alcohol Concern (UK), Alcohol Action Ireland, and FARE (Australia). Industry-funded bodies were...
(Columbia University's Mailman School of Public Health) Researchers confirm the lower risk of breast cancer from multiple pregnancies and from breast feeding seen in average risk women extends to those at the highest risk of breast cancer, according to the largest prospective study of BRCA1 and BRCA2 mutations carriers to date. Women with BRCA1 mutations who had two, three or four or more full-term pregnancies were at 21 percent, 30 percent, and 50 percent decrease risk of breast cancer compared to women with a single full-term pregnancy.
In conclusion, the NR5A orphan nuclear receptors are nonredundant factors that are crucial regulators of a panoply of biological processes, across multiple reproductive tissues. PMID: 30810078 [PubMed - in process]
Publication date: Available online 26 February 2019Source: Reproductive ToxicologyAuthor(s): Hui-Chen Wu, Barbara A. Cohn, Piera M. Cirillo, Regina M. Santella, Mary Beth TerryAbstractStudies measuring dichlorodiphenyltrichloroethane (DDT) exposure during key windows of susceptibility including the intrauterine period suggest that DDT exposure is associated with breast cancer risk. We hypothesized that prenatal DDT exposure is associated with DNA methylation. Using prospective data from 316 daughters in the Child Health and Development Study, we examined the association between prenatal exposure to DDTs and DNA methylation...
Publication date: March 2019Source: European Journal of Obstetrics &Gynecology and Reproductive Biology, Volume 234Author(s): Joana Portela Dias, Mariana Coroado, António Braga, Ana Galvão, Jorge Braga
Conclusion Overall, pregnancy outcomes before and after breast cancer diagnosis are reassuring. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text