Vaccine study confirms sensitivity of cholera test

(PLOS) Recently, the sensitivity of fecal microbiological cultures for detecting cholera has come under question. Researchers reporting in PLOS Neglected Tropical Diseases investigated this claim using a 'vaccine probe' analysis of a completed cholera vaccine cluster randomized trial to support the sensitivity of conventional microbiological culture for cholera.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Publication date: Available online 20 April 2019Source: BiologicalsAuthor(s): Mozhdeh Namvarpour, Majid Tebianian, Reza Mansouri, Seyyed Mahmoud Ebrahimi, Shiva KashkooliAbstractAccording to some difficulties against tuberculosis (TB) vaccination, development of new TB vaccines has been noted in recent years. Selection of proper route for vaccination is one of the most important factors for induction of good immune responses. Hence, in this study, the effects of different administration routes, including intranasal (I.N), subcutaneous (S.C) and intramuscular (I.M) on immune responses against Mycobacterium tuberculosis ESAT...
Source: Biologicals - Category: Biology Source Type: research
[WHO] An oral cholera vaccine (OCV) campaign targeting some 487 825 people began Tuesday in Zimbabwe in the two districts most affected by cyclone Idai.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Abstract The aim of this study was to observe the intestinal mucosal/systemic responses triggered by intranasal vaccination using recombinant Trichinella spiralis serine protease (rTsSP) and its capacity to elicit immune protection against larva challenge in a murine model. rTsSP coupled with cholera toxin B subunit (CTB) was used to vaccinate mice via intranasal route. The results revealed that intranasal vaccination with rTsSP plus CTB elicited significantly intestinal local sIgA response and a TsSP-specific systemic antibody response in vaccinated mice. Furthermore, more goblet cells/acidic mucins and IgA-secre...
Source: Experimental Parasitology - Category: Parasitology Authors: Tags: Exp Parasitol Source Type: research
[The Herald] Government, with support from UNICEF, will start rolling out mass cholera vaccination in Chimanimani and Chipinge today targeting about 500 000 people.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
We describe here a powerful method for identifying B cells that recognize membrane antigens expressed on cells. The technique depends on two characteristics of the interaction between a B cell and an antigen-expressing cell: antigen-receptor-mediated extraction of antigen from the membrane of the target cell, and B cell activation. We developed the method using influenza hemagglutinin as a model viral membrane antigen, and tested it using acetylcholine receptor (AChR) as a model membrane autoantigen. The technique involves co-culturing B cells with adherent, bioorthogonally labeled cells expressing GFP-tagged antigen, and ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
[WHO] 10 April 2019, Maputo - The Ministry of Health in Mozambique has concluded a successful six-day emergency cholera vaccination campaign that reached more than 800 000 people in four districts affected by Cyclone Idai.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
An Associated Press investigation finds that Yemen's U.S.-backed government, Houthi rebels hindered relief efforts as the country suffered the worst cholera outbreak in modern times
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
[WHO] Thousands of people received the oral cholera vaccine today as part of a six-day emergency vaccination campaign run by the Ministry of Health in Mozambique to help prevent spread of cholera.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[AIM] Maputo -The vaccination campaign against cholera in the central Mozambican province of Sofala has reached almost 70 per cent of its target of 884,000.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[AIM] Maputo -About 32,000 people received the oral vaccine against cholera in the central Mozambican city of Beira on Wednesday, the first day of the vaccination campaign, according to Health Minister Nazira Abdula, cited in Friday's issue of the independent daily "O Pais".
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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