A tale of two eras: the story of autologous stem cell transplantation with and without thiotepa for primary central nervous system lymphoma

Primary central nervous system lymphoma (PCNSL) is an aggressive and rare form of extranodal non-Hodgkin lymphoma that occurs in the brain, spinal cord, eyes, or cerebral spinal fluid (CSF)1 with highest incidence in patients over 65.2 Poor performance status at diagnosis often impede enrollment in clinical trials. Thus, therapeutic recommendations are based on a few randomized trials, single arm phase 2 trials and retrospective studies. There is no uniform consensus on the optimal treatment strategy for PCNSL patients.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research