PGRMC1 can trigger estrogen-dependent proliferation of breast cancer cells: estradiol vs. equilin vs. ethinylestradiol.

CONCLUSIONS: PGRMC1 increases strongly the estrogen-dependent breast cell proliferation. The proliferating effects of EE may be lower compared to E2 and EQ. This could have importance in comparing hormone therapy and contraception. Thus, PGRMC1 not only could predict the risk using progestogens but also of different estrogens. PMID: 30862292 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30862292?dopt=Abstract

Source: Climacteric - March 11, 2019 Category: Geriatrics Authors: Li X, Ruan X, Gu M, Mueck AO Tags: Climacteric Source Type: research