Prunella vulgaris: A comprehensive review of chemical constituents, pharmacological effects and clinical applications.

Prunella vulgaris: A comprehensive review of chemical constituents, pharmacological effects and clinical applications.
Curr Pharm Des. 2019 Mar 13;:
Authors: Wang SJ, Wang XH, Dai YY, Ma MH, Rahman K, Nian H, Zhang H
Abstract
Prunella vulgaris (PV) is a perennial herb belonging to the Labiate family and is widely distributed in northeastern Asian countries such as Korea, Japan, and China. It is reported to display diverse biological activities including anti-microbial, anti-cancer, and anti-inflammation as determined by in vitro or in vivo studies. So far, about 200 compounds have been isolated from PV plant and majority of these have been characterized mainly as triterpenoids, sterols and flavonoids, followed by coumarins, phenylpropanoids, polysaccharides and volatile oils. This review summarizes and analyzes the current knowledge on the chemical constituents, pharmacological activities, mechanisms of action and clinical applications of the PV plant including its potential as a future medicinal plant. Although some of the chemical constituents of the PV plant and their mechanism of action have been investigated the biological activities of many of these remain unknown and further clinical trials are required to further enhance its reputation as a medicinal plant.
PMID: 30864498 [PubMed - as supplied by publisher]

Source: Current Pharmaceutical Design - March 12, 2019 Category: Drugs & Pharmacology Authors: Wang SJ, Wang XH, Dai YY, Ma MH, Rahman K, Nian H, Zhang H Tags: Curr Pharm Des Source Type: research