Reversine induces cell cycle arrest and apoptosis via upregulation of the Fas and DR5 signaling pathways in human colorectal cancer cells.

In conclusion, Reversine treatment suppressed tumor progression by the inhibition of cell proliferation, induction of cell cycle arrest and induction of apoptosis via upregulation of the Fas and DR5 signaling pathways in human colorectal cancer cells. The present study indicated that reversine may be used as a novel anticancer agent in human colorectal cancer.
PMID: 30864676 [PubMed - as supplied by publisher]

Source: International Journal of Oncology - March 12, 2019 Category: Cancer & Oncology Authors: Park YL, Ha SY, Park SY, Choi JH, Jung MW, Myung DS, Kim HS, Joo YE Tags: Int J Oncol Source Type: research