Gabapentin versus Transdermal Fentanyl Matrix for the Alleviation of Chronic Neuropathic Pain of Radicular Origin: A Randomized Blind Multicentered Parallel-Group Noninferiority Trial.

This study demonstrated that the analgesic effect of fentanyl matrix is noninferior in comparison with gabapentin and supports the use of fentanyl matrix as an effective and safe treatment for moderate-to-severe chronic neuropathic pain. This trial is registered with NCT01127100. PMID: 30863474 [PubMed - in process]
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research

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Conclusions: In contrast to a study conducted by Sun et al, in which there was a statistical difference in knee pain between the SP and IP surgical approaches, we did not detect any statistical or clinical differences in knee pain between the SP and IP surgical approaches among patients with greater than 12 months of follow-up. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Objectives: (1) To assess the correlation of psychosocial factors and long-term outcomes of proximal humerus fractures all in surgical repair; (2) to identify specific psychosocial factors with favorable and unfavorable outcomes; and (3) to assess the correlation between DSM-V mental health diagnoses and long-term Disabilities of Arm, Shoulder, and Hand (DASH) scores. Design: Prospective cohort study. Setting: Academic medical center. Patients: Patients were screened and identified on presentation to the emergency department or in the clinical office for inclusion in an institutional review board–approved ...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Publication date: Available online 20 August 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Megan N. Wasson
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusion Results provide insights into modifiable risk factors for morning fatigue. These risk factors can be used to develop more targeted interventions. Implications for Practice Patients in the high and very high morning fatigue classes experienced high symptom and comorbidity burdens and significant decrements in functional status. Using this information, clinicians can identify patients who are at an increased risk for higher levels of morning fatigue and prescribe interventions to improve this devastating symptom.
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
Background Cancer patients often have other noncancer medical conditions. Presence of comorbidities negatively affects cancer survival. Objective The aim of this study was to investigate comorbidity, risk factors for comorbidity, and how comorbidity was associated with symptoms and quality of life in patients being treated for breast cancer. Methods One hundred and one breast cancer chemotherapy outpatients completed this study. Comorbid conditions, weight, height, and smoking status were identified by chart review. Symptoms and quality of life were self-reported using psychometrically sound instruments. Log-linear...
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
Background Depressive symptoms are prevalent in patients with cancer and are heterogeneous; however, existing methods of grouping patients with heterogeneous symptoms have limitations. Objectives The purpose of this study was to identify depressive symptom clusters in patients with cancer using a data-driven method and to explore their relationships with symptoms of anxiety and posttraumatic stress disorder. Methods Data from 247 patients were analyzed in this cross-sectional study. Latent class analysis was used to identify depressive symptom clusters, using 9 depressive symptoms from the Patient Health Questionna...
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
Conclusion This study describes what makes the subgroup of pain patients most affected by their pain special according to associated factors and comorbidity We found that they were distinguished by a high degree of psychiatric comorbidity, low physical functioning and extreme levels of symptom preoccupation/hypervigilance. Many severe symptoms additional to pain (e.g. depression/anxiety, tiredness, disturbed sleep, lack of concentration, constipation) were reported. The group seems hypervigilant, overwhelmed with a multitude of different symptoms on a high severity level. Implications When treating this complex group, the ...
Source: Scandinavian Journal of Pain - Category: Anesthesiology Source Type: research
Conclusion Doctors often assure parents that vaccines are safe, using phrases like “one in a million” and “rare” to describe adverse reactions. Yet, with sad stories like RD’s, thousands of adverse events reported to VAERS, and the creation of a special court for vaccine injuries, informed parents know those vaccine safety claims are simply not true. If you have not already done so, please consider the overall safety of vaccinations. A federal program has awarded billions of dollars, through an arduous, emotionally painful process, to people whose family members have suffered injury or death a...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Case Reports on Vaccine Injury Human Missy Fluegge Patricia Finn transverse myelitis truth about vaccines United States Court of Federal Claims Vaccine Court VAERS Varicella vaccine Source Type: blogs
Conclusion. Duloxetine 60 mg was effective and well tolerated in Japanese CLBP patients. Level of Evidence: 2
Source: Spine - Category: Orthopaedics Tags: Randomized Trial Source Type: research
This year marks the 25th anniversary of the Persian Gulf War. It was fought in late 1990 through early 1991 by a U.S.-led coalition of 34 countries against Iraq in response to Saddam Hussein's invasion of Kuwait. It also was the first U.S. war to be waged after the advent of the 24-hour cable television news cycle. The conflict was accompanied by memorably intense and round-the-clock coverage on CNN. But there've been few recognitions of the war's 25-year milestone on the cable news networks, let alone in broadcast or print media. For David Winnett, a Gulf War combat veteran who climbed the ranks from private to capta...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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