pH-responsive catalytic mesocrystals for chemodynamic therapy via ultrasound-assisted Fenton reaction

Publication date: 1 August 2019Source: Chemical Engineering Journal, Volume 369Author(s): Jian Chen, Xiaobo Wang, Yibiao Liu, Huili Liu, Fengli Gao, Chong Lan, Baocheng Yang, Shouren Zhang, Yongju GaoAbstractWe develop pH-responsive GOD@CaCO3-Fe3O4 particles as catalytic nanomedicine for chemodynamic therapy through ultrasound-assisted Fenton reaction. By loading glucose oxidase (GOD) in the interior of the particles, GOD can be well protected and effectively delivered to catalyze glucose in cancer cells. A considerable amount of H2O2 is then generated for Fenton reaction by reacting with Fe3O4 nanoparticles. The introduction of ultrasound irradiation can significantly improve Fenton reaction efficiency in tumors owing to ultrasonic cavitation. Highly toxic hydroxyl radicals are then generated in abundance to kill cancer cells. Good cancer therapeutic effect was realized both in vitro and in vivo via this ultrasound-chemodynamic strategy based on the designed particles, providing a novel strategy for efficient cancer therapy.Graphical abstract
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research