The pharmacokinetic challenge of voriconazole therapy for cerebral aspergillosis in patients treated with ibrutinib

Source: Critical Care - Category: Intensive Care Authors: Tags: Letter Source Type: research

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Publication date: Available online 20 February 2020Source: IDCasesAuthor(s): Heather L. Clark, Hugo E. Valencia, Jennifer J. Findeis-Hosey, Steve N. GeorasAbstractAspergillus molds are ubiquitous environmental molds that can cause devastating invasive infections in immunocompromised patients. These infections often go unrecognized in critically ill patients. This case describes a 68 year-old female resident of a long-term nursing facility with history of dementia, nonalcoholic fatty liver disease with cirrhosis, chronic kidney disease stage III and insulin-dependent type 2 diabetes who presented with vomiting, diarrhea and...
Source: IDCases - Category: Infectious Diseases Source Type: research
ConclusionsWith pulsed echinocandin therapy, azole ‐intolerant or pan‐resistant CPA patients have similar mortality rates to azole‐naïve CPA patients. Pulsed echinocandin therapy may present a strategy to stabilize CPA in patients with pan‐resistance or intolerance to, azole therapy.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
Invasive aspergillosis (IA) is a major cause of critical illness in immunocompromised (IC) patients. However, current fungal tests are limited. Disease-specific gene expression patterns in circulating host cells show promise as novel diagnostics, however it is unknown whether such a ‘signature’ exists for IA and the effect of iatrogenic immunosuppression on any such biomarkers.Male BALB/c mice were separated into 6 experimental groups based on Aspergillus fumigatus inhalational exposure and IC status (no immunosuppression, cyclophosphamide, and corticosteroids).
Source: Translational Research - Category: Research Authors: Source Type: research
Authors: Díaz Alcázar MDM, Ruiz Escolano E, Casado Caballero FJ, Cervilla Sáez de Tejada E Abstract A 72-year-old female presented with abdominal pain and constipation and intestinal dilation was found. Abdominal computed tomography showed two areas of thickening and stenosis in the proximal jejunum and preterminal ileum, with an unknown etiology. Exploratory laparotomy was proposed but the patient suffered a sudden and progressive decrease in consciousness. Cranial computed tomography showed an ischemic area and a midline shift. Brain biopsies suggested infection by Aspergillus Fumigatus. Desp...
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Aspergillosis is  a life‐threatening infection mostly affecting immunocompromised individuals and primarily caused by the saprophytic fungusAspergillus  fumigatus. At the host –pathogen interface, both cellular and humoral components of the innate immune system are increasingly acknowledged as essential players in the recognition and disposal of this opportunistic mold. Fundamental hereof is the contribution of the complement system, which deploys all three activation p athways in the battle againstA.  fumigatus, and functionally cooperates with other soluble pattern recognition molecules, including ...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Review Article Source Type: research
Condition:   Invasive Pulmonary Aspergillosis Interventions:   Drug: Amphotericin B Liposomal 50 MG;   Other: Placebo Sponsor:   Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Aspergillosis is  a life‐threatening infection mostly affecting immunocompromised individuals and primarily caused by the saprophytic fungusAspergillus  fumigatus. At the host –pathogen interface, both cellular and humoral components of the innate immune system are increasingly acknowledged as essential players in the recognition and disposal of this opportunistic mold. Fundamental hereof is the contribution of the complement system, which deploys all three activation p athways in the battle againstA.  fumigatus, and functionally cooperates with other soluble pattern recognition molecules, including ...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Review Article Source Type: research
ConclusionGiven our experience and the literature review, a fungal etiology should be considered early in the course of malignant external otitis unresponsive to a conventional broad spectrum antibiotic therapy, with the need for a tissue biopsy to confirm the diagnosis.
Source: Infection - Category: Infectious Diseases Source Type: research
Invasive aspergillosis is a fungal infection that occurs mainly in immunocompromised patients. It is responsible for a high degree of mortality and is invariably unresponsive to conventional antifungal treatme...
Source: BMC Microbiology - Category: Microbiology Authors: Tags: Research article Source Type: research
Conclusion: We conclude that basophil and lymphocyte activation tests could enhance the diagnosis of allergic mycosis, compared to usual humoral markers. Further studies with larger cohorts and addressing both mold extracts and mold relevant molecules are needed in order to confirm and extend the application of this personalized medicine approach.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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