BU: Central American kidney disease epidemic linked to occupational heat exposure

(Boston University School of Medicine) For two decades, Nicaragua and El Salvador have seen increasing mortality from an unusual form of chronic kidney disease (CKD), also called Mesoamerican Nephropathy (MeN). The disease has disproportionately affected sugarcane and other agricultural workers, and appears to be unrelated to traditional kidney disease risk factors such as diabetes.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 27 February 2019Source: American Journal of Kidney DiseasesAuthor(s): Lyanne Gallo-Ruiz, Caryn M. Sennett, Mauricio Sánchez-Delgado, Ana García-Urbina, Tania Gámez-Altamirano, Komal Basra, Rebecca L. Laws, Juan José Amador, Damaris Lopez-Pilarte, Yorghos Tripodis, Daniel R. Brooks, Michael D. McClean, Joseph Kupferman, David Friedman, Aurora Aragón, Marvin González-Quiroz, Madeleine K. ScammellRationale &ObjectiveIn Central America, there is a high prevalence of chronic kidney disease (CKD) of nontraditional etiology often observed among agric...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Obesity is the global epidemic of the 21st century: about 1.5 billion adults worldwide are overweight, and among them, about 200 million men and 300 million women are obese [1]. In some countries, the prevalence of obesity has exceeded 50%, as in Tonga (men), and in Kuwait, Kiribati, Micronesia, Libya, Qatar, Tonga and Samoa (women) [2]. The prevalence of overweight and obesity are also increasing in children and adolescents in developed (about 25%) and in developing countries (about 13%) [2]. Obesity has been associated with many comorbidities, including type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (N...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
There is an epidemic of chronic kidney disease (CKD) clustering in rural communities, predominantly in a number of low- and middle-income countries.1 Tens of thousands of working-aged adults are estimated to have died from the disease in Central America2 with similar numbers in Sri Lanka.3 Similar diseases have been reported elsewhere, such as rural regions or communities in India and North and West Africa. Those affected do not have common risk factors or underlying conditions that lead to CKD, such as diabetes, immune-mediated glomerulonephritis, or structural renal disease.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrologists Sans Fronti ères Source Type: research
Abstract Diabetes and hypertension are the major causes of chronic kidney disease (CKD). Epidemiological studies within the last few decades have revealed that obesity-associated renal disease is a emerging epidemic and that the increasing prevalence of obesity parallels the increased rate of CKD. This has led to the inclusion of obesity as an independent risk factor for CKD. A major complication when studying the relationship between obesity and renal injury is that cardiovascular and metabolic disorders that may result from obesity including hyperglycemia, hypertension, and dyslipidemia, or the cluster of these ...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Abstract Chronic kidney disease (CKD) has become epidemic worldwide. Mitochondrial reactive oxygen species (ROS)-induced oxidative stress is an important mediator of CKD, and Prx3 plays a critical role in maintenance of mitochondrial ROS. The present study examined the role of Prx3 in the context of fibrosis, a common feature of CKD, using Prx3 KO mice under obstructive and diabetic stress. Prx3 deficiency accelerated fibrosis and inflammation accompanied by mitochondrial oxidative stress in obstructed and diabetic kidneys as well as in proximal tubular epithelial (mProx) cells. In addition, Prx3 deficiency induce...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research
As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of NAFLD which can be characterized as non-alcoholic steatohepatitis (NASH) is a potentially progressive liver disease that can lead to cirrhosis, hepatocellular carcinoma, liver transplantation, and death; it is associated with extrahepatic manifestations such as chronic kidney disease cardiovascular disease and sleep apnea.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Public Health Source Type: research
As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of NAFLD which can be characterised as non-alcoholic steatohepatitis (NASH) is a potentially progressive liver disease that can lead to cirrhosis, hepatocellular carcinoma, liver transplantation, and death. NAFLD is also associated with extrahepatic manifestations such as chronic kidney disease, cardiovascular disease and sleep apnoea.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Public Health Source Type: research
Publication date: December 2018Source: Value in Health Regional Issues, Volume 17Author(s): Ramiro E. Gilardino, Eduardo González-Pier, Claudia BrabataAbstractEnd-stage renal disease, the last and most severe stage of chronic kidney disease, represents a major and rising concern for countries in Latin America, driven in large part by aging populations and the near-epidemic rises in diabetes, obesity, and hypertension. This places a great clinical, economic, and social burden on the region’s health systems. During the ISPOR 6th Latin America Conference held in Sao Paulo, Brazil, in September 2017, an educationa...
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
We’re excited to share the topic and questions for this week’s #HITsm chat happening Friday, 8/24 at Noon ET (9 AM PT). This week’s chat will be hosted by Colton Ortolf (@ColtonOrtolf) who blogs at tech prescribed on the topic of “The Role of Technology in Chronic Disease Management“. Chronic disease is an incredibly broad term, but it can be simply defined as “a physical or mental health condition that lasts more than one year and causes functional restrictions or requires ongoing monitoring or treatment.” In all, 86% of $2 trillion in US healthcare expenditures eac...
Source: EMR and HIPAA - Category: Information Technology Authors: Tags: #HITsm Digital Health Healthcare HealthCare IT #HITsm Topics Chronic Care Management Chronic Disease Management Colton Ortolf tech prescribed Source Type: blogs
Publication date: Available online 5 June 2018Source: Seminars in Cell &Developmental BiologyAuthor(s): Robert L. ChevalierAbstractThere is a global epidemic of chronic kidney disease (CKD) characterized by a progressive loss of nephrons, ascribed in large part to a rising incidence of hypertension, metabolic syndrome, and type 2 diabetes mellitus. There is a ten-fold variation in nephron number at birth in the general population, and a 50% overall decrease in nephron number in the last decades of life. The vicious cycle of nephron loss stimulating hypertrophy by remaining nephrons and resulting in glomerulosclerosis h...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
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