Prevalence of < b > < i > C9ORF72 < /i > < /b > Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus

Conclusion: This is the first study cohort identifying the underlyingC9ORF72 expansion in patients with iNPH providing evidence for the potential comorbidity between iNPH and the FTLD-ALS spectrum. Analysis of theC9ORF72 expansion should be considered for patients with probable iNPH presenting with frontal atrophy and personality changes or other severe psychiatric symptoms.Dement Geriatr Cogn Disord 2019;47:91 –103
Source: Dementia and Geriatric Cognitive Disorders - Category: Geriatrics Source Type: research