Vancomycin Removal During High-Volume Peritoneal Dialysis in Acute Kidney Injury Patients.

Vancomycin Removal During High-Volume Peritoneal Dialysis in Acute Kidney Injury Patients. Perit Dial Int. 2019 Mar-Apr;39(2):183-187 Authors: Ponce D, Zamoner W, Freitas FM, Balbi A, Awdishu L Abstract Studies on vancomycin pharmacokinetics in acute kidney injury (AKI) patients on high-volume peritoneal dialysis (HVPD) are lacking. We studied the pharmacokinetics of intravenous (IV) vancomycin in AKI patients treated by HVPD who received a prescribed single IV dose of vancomycin (15 - 20 mg/kg total body weight) to determine the extent of vancomycin removal and to establish vancomycin dosing guidelines for the empirical treatment of AKI patients receiving HVPD. The application of 18 mg/kg vancomycin every 48 - 72 hours in AKI patients undergoing HVPD was required to maintain therapeutic concentrations. PMID: 30858287 [PubMed - in process]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research