The effects of oxidative stress on the development of atherosclerosis.

The effects of oxidative stress on the development of atherosclerosis. Biol Chem. 2018 Dec 01;: Authors: Khosravi M, Poursaleh A, Ghasempour G, Farhad S, Najafi M Abstract Atherosclerosis is a cardiovascular disease known widely in the world. Several hypothesizes are suggested to be involved in the narrowing of arteries during process of atherogenesis. The oxidative modification hypothesis is related to oxidative and anti-oxidative imbalance and is most investigated. The aim of this study was to review the role of oxidative stress in atherosclerosis. Furthermore, it describes the roles of oxidative/anti-oxidative enzymes and compounds in the macromolecular and lipoprotein modifications and triggering the inflammatory events. The reactive oxygen (ROS) and reactive nitrogen (RNS) species are the most important endogenous sources produced by non-enzymatic and enzymatic (MPO, NADH oxidase and LO) reactions that may be balanced with anti-oxidative compounds (GSH, Polyphenols and Vitamins) and enzymes (Gpx, Prdx, SOD and PON). However, the oxidative and anti-oxidative imbalance cause the involvement of cellular proliferation and migration signaling pathways and macrophage polarization led to the formation of atherogenic plaques. On the other hand, the immune occurrences and the changes in extra cellular matrix remodeling can develop atherosclerosis process. PMID: 30864421 [PubMed - as supplied by publisher]
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research