Robust clinical benefit of multi-target deep brain stimulation for treatment of Gilles de la Tourette syndrome and its comorbidities

Deep brain stimulation (DBS) has emerged as an efficacious modality for the treatment of medically refractory neuropsychiatric diseases. Traditional DBS approaches have used a single pair of bilateral leads to treat diseases with relatively well-defined disease networks and targets [1]. However, the optimal approach for Gilles de la Tourette syndrome (GTS) has yet to be determined. GTS is complicated by having more than 4 proposed DBS targets for the motor system and common comorbidities including major depressive depression (MDD) and obsessive-compulsive disorder (OCD) [2,3].

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 3, 2019 Category: Neurology Authors: Bina Kakusa, Sabir Saluja, William J. Tate, Flint M. Espil, Casey H. Halpern, Nolan R. Williams Source Type: research