Liposomes produced by microfluidics and extrusion- a comparison for scale-up purposes

Publication date: Available online 13 March 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Vidhi M. Shah, Duc X. Nguyen, Pragnesh Patel, Brianna Cote, Adel Al-Fatease, Yvonne Pham, Man Gia Huynh, Yeonhee Woo, Adam WG. AlaniGraphical abstractGraphical abstract shows two methods to prepare liposomes: extrusion, which has challenges with scale-up, and microfluidics, which is scale-up efficient. Both methods produce liposomes that are identical in size and in vitro and in vivo behavior. Thus, substitution of extrusion, the gold standard of making liposomes, with a precise and scalable microfluidics platform is a viable option.

Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 14, 2019 Category: Nanotechnology Source Type: research