Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening

Rhoptry protein 18 (ROP18) is a key virulence factor of Toxoplasma gondii. The host ’s immune responses mediated by immune-related GTPases (IRGs) could be blocked by ROP18’s kinase activity. ROP18 also interacts w...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research

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Publication date: October 2019Source: Fish &Shellfish Immunology, Volume 93Author(s): Huria Marnis, Per W. Kania, Khairul Syahputra, Shaozhi Zuo, Ron P. Dirks, Kurt BuchmannAbstractHigh infection levels due to third-stage larvae of the anisakid nematode Contracaecum osculatum have been documented in cod from the eastern part of the Baltic sea during the latest decades. The nematode larvae mainly infect the liver of Baltic cod and prevalence of infection has reached 100% with a mean intensity up to 80 parasites per host in certain areas and size classes. Low condition factors of the cod have been observed concomitant wi...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: October 2019Source: Fish &Shellfish Immunology, Volume 93Author(s): Ophélie Gervais, Bruno Chollet, Christine Dubreuil, Serena Durante, Chunyan Feng, Cyril Hénard, Cyrielle Lecadet, Delphine Serpin, Renault Tristan, Isabelle ArzulAbstractThe protozoan parasite Bonamia ostreae has been associated with the decline of flat oyster Ostrea edulis populations in some European countries. Control of shellfish diseases mostly relies on prevention measures including transfer restrictions and stock management measures such as breeding programmes. These prevention and mitigation measures require a be...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 23 August 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Claudia Herrera, Carine Truyens, Eric Dumonteil, Jackeline Alger, Sergio Sosa-Estani, Maria Luisa Cafferata, Luz Gibbons, Alvaro Ciganda, Maria Luisa Matute, Concepcion Zuniga, Yves Carlier, Pierre BuekensAbstractTrypanosoma cruzi, the causative agent of Chagas disease, exhibits a high genetic variability and has been classified into six discrete typing units (DTUs) named TcI-TcVI. This genetic diversity is believed to be associated with clinical characteristics and outcomes, but evidences supporting such associations ha...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
In this study, we genetically characterised Monogenea found on the gill of common carp in Iran. In total, 5603 parasites were recovered from 112 fish. The parasites were first identified morphologically as Dactylogyrus extensus, D. anchoratus, D. vastator, D. minutus, D. achmerowi and Gyrodactylus sprostonae. Representative samples were then subjected to sequencing. This is one of the first studies which has provided both morphological and sequence data for Dactylogyrus spp. and G. sprostonae. Our findings provide a foundation for future research into the genetic make-up of these economically significant parasites and the ...
Source: Parasitology International - Category: Parasitology Source Type: research
ConclusionAlthough malaria remains a serious disease affecting millions of people, medicinal plants while used extensively, have not been given the attention warranted for further investigation.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 21 August 2019Source: Ticks and Tick-borne DiseasesAuthor(s): R. Megía-Palma, D. Paranjpe, P. Blaimont, R. Cooper, B. SinervoAbstractIt is generally accepted that parasites exert negative effects on their hosts and that natural selection favors specific host responses that mitigate this impact. It is also known that some components of the host immune system often co-evolve with parasite antigens resulting in a host-parasite arms race. In addition to immunological components of the anti-parasitic response, host behavioral responses are also important in this arms race and natural se...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Kit BD Max Enteric Parasite Panel EU; Catalog # 442960
Source: Medical Device Recalls - Category: Medical Devices Source Type: alerts
Three-year review says new vaccines for eradicating disease are only 40% effectiveMalaria will not be eradicated in the foreseeable future even though it is achievable and would save millions of lives, according to World Health Organization (WHO) experts following a three-year review.The WHO remains committed to the “disappearance of every single malaria parasite from the face of the planet”, as it has been since the UN organisation was launched in 1948, said Dr Pedro Alonso, the director of its global malaria programme.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: World Health Organization Malaria World news Society Science Medicine Medical research Global development Source Type: news
Although parasitic isopods can negatively affect the reproduction and ingestion of several commercially important crustaceans, little is known regarding the mechanisms that underlie these effects.
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Schistosomiasis is a prevalent but neglected tropical disease caused by parasitic trematodes of the genus Schistosoma, with the primary disease-causing species being S. haematobium, S. mansoni and S. japonicum. M...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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