Biguanides exert antitumoral actions in pituitary tumor cells through AMPK-dependent and -independent mechanisms.

CONCLUSION: Altogether, our data unveil clear antitumoral effects of biguanides on PitNET cells, opening new avenues to explore their potential as drugs to treat these pathologies.
PMID: 30860580 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - March 11, 2019 Category: Endocrinology Authors: Vázquez-Borrego MC, Fuentes-Fayos AC, Herrera Martínez AD, L-López F, Ibáñez-Costa A, Moreno Moreno P, Alhambra-Expósito MR, Barrera-Martín A, Blanco-Acevedo C, Dios E, Venegas-Moreno E, Solivera J, Gahete MD, Soto-Moreno A, Gálvez-Moreno MA, Cast Tags: J Clin Endocrinol Metab Source Type: research