Enteroendocrine connections in congenital isolated GH deficiency due to a GHRH receptor gene mutation.

CONCLUSIONS: Untreated IGHD is associated to increased GLP-1 secretion and reduced post-prandial ghrelin and hunger attenuation in response to a mixed meal. These enteroendocrine connections can result into a favourable outcome in terms of environmental adaptation, guaranteeing appropriate food intake, and can confer metabolic benefits. PMID: 30860584 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30860584?dopt=Abstract

Source: The Journal of Clinical Endocrinology and Metabolism - March 11, 2019 Category: Endocrinology Authors: Oliveira-Santos AA, Salvatori R, Nogueira MC, Bueno AC, Barros-Oliveira CS, Leal ÂCGB, Marinho CG, Damascena NP, Oliveira DA, Melo MA, Oliveira CRP, da Costa FO, Dos Santos JSS, Santos PFC, Campos VC, Santos EG, Melo EV, Barbosa MLA, Rocha IES, de Castro Tags: J Clin Endocrinol Metab Source Type: research