Doctors aren't discussing CT lung screening with patients

When it comes to CT lung cancer screening, physicians are missing a golden...Read more on AuntMinnie.comRelated Reading: U.S. cancer sites boast high access to CT lung screening Pulmonologists more open to CT lung cancer screening Are patients adequately informed about CT lung screening? Patient outreach may boost uptake for CT lung screening 3 steps to personalized CT lung cancer screening
Source: Headlines - Category: Radiology Source Type: news

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A new machine learning algorithm outperformed existing methods in differentiating benign nodules from cancer.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Abstract KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast cancer. Here, we developed a novel anchor-like DNA (alDNA) electrochemical sensor for the detection of KRAS point mutation level (the concentration ratio of the specific KRAS point mutant DNA (M-DNA) to the total DNA (t-DNA) of both mutant and wild-type DNAs carrying the same allele). Compared to those conventional ligation-based DNA sensors, the proposed alDNA sensor achieved the one-step capture of both wild-type and mutant DNA, and the subseq...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Publication date: Available online 17 March 2019Source: Journal of Molecular StructureAuthor(s): G. Sasikumar, S. Arulmozhi, A. Ashma, A. Sudha, S.J. Askar aliAbstractThis research work was emphasized about synthesis of mixed ligands of Co(II), Ni(II), Cu(II) and Zn(II) complexes of the type [M(L)(phen)] 1–4 and [M(L)(bpy)] 5–8 where, L = potassium (S, E)-2-((5-bromo-2-hydroxybenzylidene)amino)propanoate (derived from 5-bromosalicylaldehyde and l-alanine), phen = 1, 10 phenanthroline and bpy = 2, 2′-bipyridyl. Both phen and bpy act as an auxiliary ligand. The synthesized metal(II) complexes ch...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
(NRG Oncology) Prophylactic cranial irradiation (PCI), a technique used to prevent the clinical development of brain metastases, is established as a standard approach for many patients with small cell lung cancer (SCLC) after initial therapy. While studies established that PCI decreases the incidence of brain metastases for patients with locally advanced non-small cell lung cancer (LA-NSCLC), there is no established indication for its use for such NSCLC patients.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Epithelial-to-mesenchymal transition (EMT) results in changes that promote de-differentiation, migration, and invasion in non-small cell lung cancer (NSCLC). While it is recognized that EMT promotes altered en...
Source: Cell Communication and Signaling - Category: Molecular Biology Authors: Tags: Research Source Type: research
Low-dose computed tomography (LDCT) screening can detect early lung cancers in smokers with a history of occupational asbestos exposure, new research shows.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news
Volume 47, Issue 1, December 2019, Page 1014-1021 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - Category: Biotechnology Authors: Source Type: research
AbstractChanges in expression of histone deacetylases (HDACs), which epigenetically regulate chromatin structure, and mutations and amplifications of theEGFR gene, which codes for the epidermal growth factor receptor (EGFR), have been reported in glioblastoma (GBM), the most common and malignant type of brain tumor. There are likely interplays between HDACs and EGFR in promoting GBM progression, and HDAC inhibition can cooperate with EGFR blockade in reducing the growth of lung cancer cells. Here, we found that either HDAC or EGFR inhibitors dose-dependently reduced the viability of U87 and A-172 human GBM cells. In U87 ce...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
e Punyadeera Objectives: In non-small cell lung cancers (NSCLC), tumour biopsy can often be an invasive procedure. The development of a non-invasive methodology to study genetic changes via circulating tumour cells (CTCs) is an appealing concept. Whilst CTCs typically remain as rare cells, improvements in epitope-independent CTC isolation techniques has given rise to a greater capture of CTCs. In this cross sectional study, we demonstrate the capture and characterization of NSCLC CTCs for the clinically actionable markers epidermal growth factor receptor (EGFR) alterations, anaplastic lymphoma kinase (ALK) rearrange...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractProstate cancer is the second leading cause of death from cancer, behind lung cancer, for men in the U. S, with nearly 30,000 deaths per year. A key problem is the difficulty in distinguishing, after biopsy, between significant cancers that should be treated immediately and clinically insignificant tumors that should be monitored by active surveillance. Prostate cancer has been over-treated; a recent European randomized screening trial shows overtreatment rates of 40%. Overtreatment of insignificant tumors reduces quality of life, while delayed treatment of significant cancers increases the incidence of metastatic ...
Source: Health Care Management Science - Category: Hospital Management Source Type: research
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