Heart test trial aimed at reducing strokes begins in East Anglia

Scientists hope the study will help reduce premature deaths among people with irregular heartbeats.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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More than 570 Upstate University Hospital nurses hold certifications in a variety of specialties, from stroke care to in-flight nursing excellence.
Source: SUNY Upstate Medical - Category: Universities & Medical Training Source Type: news
Abdelali Agouni, Aijaz S. Parray, Naveed Akhtar, Fayaz A. Mir, Paula J. Bourke, Sujata Joseph, Deborah M. Morgan, Mark D. Santos, Muhammad F. Wadiwala, Saadat Kamran, Siveen K. Sivaraman, Ashfaq Shuaib
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: Available online 18 March 2019Source: The Lancet NeurologyAuthor(s): Magdy Selim, Lydia D Foster, Claudia S Moy, Guohua Xi, Michael D Hill, Lewis B Morgenstern, Steven M Greenberg, Michael L James, Vineeta Singh, Wayne M Clark, Casey Norton, Yuko Y Palesch, Sharon D Yeatts, Monica Dolan, Erlinda Yeh, Kevin Sheth, Kimberly Kunze, Susanne Muehlschlegel, Iryna Nieto, Jan ClaassenSummaryBackgroundIron from haemolysed blood is implicated in secondary injury after intracerebral haemorrhage. We aimed to assess the safety of the iron chelator deferoxamine mesylate in patients with intracerebral haemorrhage and to...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: April 2019Source: Revista Española de Cardiología (English Edition), Volume 72, Issue 4Author(s): Manuel Chacón-Díaz, Roberto Ruiz-Cordero, Helard Miranda-Aguilar, Josias Rios-Ortega, Fernando Córdova-Gómez, Julio Morón-Castro
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
ConclusionsData from this meta-analysis suggest that, vs warfarin, the stroke prevention effectiveness and bleeding risk of direct oral anticoagulants may differ in real-life patients with atrial fibrillation.ResumenIntroducción y objetivosDeterminar la efectividad de los anticoagulantes orales directos frente a los antagonistas de la vitamina K en pacientes con fibrilación auricular de la práctica clínica.MétodosSe realizó una revisión sistemática acorde con los estándares metodológicos de Cochrane. Los resultados de la revisión se publicaro...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
This study compared outcomes using the ACC/AHA risk algorithm and the Framingham risk score (FRS) tool in The Heart Outcomes Prevention Evaluation (HOPE) 3 study.MethodsWe compared outcomes using the ACC/AHA algorithm and the FRS with those seen in HOPE-3, which randomized participants to 10mg rosuvastatin or placebo. First co-primary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke; second co-primary outcome additionally included heart failure, cardiac arrest and revascularization.ResultsRelative risks using risk scores were similar to those observed in the H...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 19 March 2019Source: Canadian Journal of CardiologyAuthor(s): Federico Fortuni, Gabriele Crimi, Filippo Angelini, Sergio Leonardi, Fabrizio D’Ascenzo, Marco Ferlini, Marco Rolando, Arturo Raisaro, Luigi Oltrona Visconti, Maurizio Ferrario, Massimiliano Gnecchi, Gaetano M. De FerrariAbstractBackgroundThe optimal strategy and timing of revascularization in hemodynamically stable patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease is unknown. We performed a systematic review and meta-analysis to explore the comparative efficacy and safety of early c...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
The National Institutes of Health (NIH) would receive $34.4 billion in FY 2020, roughly $4.7 billion or 13 percent below the levels enacted by Congress for FY 2019, according to the President’s Budget released on March 11. The budget for NIH includes $492 million in funding made available through the 21st Century Cures Act and $150 million in mandatory funding. The leading biomedical research agency in the world would receive budget cuts across the board. All NIH centers are slated for budget reductions: National Cancer Institute: -8.7 percent National Heart, Lung, and Blood Institute: -14 percent National Inst...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
Ischemic stroke is a predominant cause of disability worldwide, with thrombolytic or mechanical removal of the occlusion being the only therapeutic option. Reperfusion bears the risk of an acute deleterious calcium-dependent breakdown of the blood-brain barrier. Its mechanism, however, is unknown. Here, we identified type 5 NADPH oxidase (NOX5), a calcium-activated, ROS-forming enzyme, as the missing link. Using a humanized knockin (KI) mouse model and in vitro organotypic cultures, we found that reoxygenation or calcium overload increased brain ROS levels in a NOX5-dependent manner. In vivo, postischemic ROS formation, in...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 18 March 2019Source: Brain StimulationAuthor(s): Brigitte C. Kaufmann, Manuela Pastore-Wapp, Maria Lübeck, Monica Koenig, Stephan Bohlhalter, Tim Vanbellingen, Dario Cazzoli, Thomas Nyffeler
Source: Brain Stimulation - Category: Neurology Source Type: research
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