Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy
AbstractCardiovascular disease affects more than 90 million Americans. Recent studies support an increased cardiovascular disease risk in inflammatory conditions, such as gout. Increased serum urate levels, or hyperuricemia, are a precursor to gout. Data from meta-analyses have shown hyperuricemia to be linked to hypertension and coronary heart disease. Similarly, gout has been associated with an increased risk of myocardial infarction, cerebrovascular accidents, and death from cardiovascular disease in randomized clinical trials. Urate-lowering therapy reduces serum urate and may decrease systemic inflammation, generation of oxidative species, and reverses endothelial dysfunction through hyperuricemia-dependent or hyperuricemia-independent pathways. Cardioprotective benefits of allopurinol, a first-line agent for the treatment of gout, have been demonstrated to potentially prevent myocardial infarction, stroke, atrial fibrillation, and other cardiovascular diseases in observational studies in select populations. Randomized controlled trials (RCTs) have also examined the role of newer urate-lowering therapies, such as febuxostat and lesinurad, and their risk of cardiovascular-specific mortality in comparison to allopurinol. A large post-marketing study of febuxostat vs. allopurinol showed higher all-cause and cardiovascular-specific mortalit y in the febuxostat group than in the allopurinol group; a major study limitation was that large numbers of patients were lost to ...
No abstract available
Sufficient levels of iron in the blood might prevent about 1 in 10 diagnoses of coronary heart disease and reduce mortality risk. The good news: Lots of healthy foods have plenty of iron.
Revel Pharmaceuticals is the result of work funded in large part by the SENS Research Foundation, with the support of its many philanthropic donors. That part of the history of the underlying research isn't covered in today's short article on the company, so it seems worth mentioning here. Cross-links are chemical bonds formed between molecules in the extracellular matrix. Some are necessary to structure and function, but other unwanted cross-links are added over the years, creating stiffness in flexible tissues such as blood vessel walls and skin. In the case of blood vessels, stiffness causes hypertension, and eventual m...
Researchers say men outnumber women in stroke therapy clinical trials, which means women may end up receiving less effective treatment.
Biopsy slides mistakenly switched; fertility specialist uses own sperm to impregnate patients; parents say daughter's stroke wasn't identified.Medscape Business of Medicine
An experimental patch works to restore function to damaged areas of the heart, which could ward off irregular heartbeats and heart failure.WebMD Health News
A recent Centers for Medicare&Medicaid Services (CMS) study found that medication use is improving among seniors and vulnerable beneficiary populations. Better adherence to medicines used to treat common chronic conditions such as high cholesterol, high blood pressure and diabetes is estimated to have saved the Medicare program between $27B and $46.6B in avoided health care costs between 2013 and 2018.
Condition: Atrial Fibrillation Intervention: Other: No intervention, as this was retrospective study. Sponsor: Aga Khan University Hospital, Pakistan Completed
Conditions: Stroke; Atrial Fibrillation Intervention: Sponsors: Sarawak General Hospital; Sarawak Heart Centre; Ministry of Health, Malaysia Recruiting