Maternal polycystic ovary syndrome and risk of neuropsychiatric disorders in offspring: prenatal androgen exposure or genetic confounding?

CONCLUSIONS: Estimates were similar when accounting for familial confounding (i.e. genetics and environmental factors shared by cousins) and stronger in girls for ADHD and ASD, potentially indicating a differential influence of prenatal androgen exposure v. genetic factors. These results strengthen evidence for a potential causal influence of prenatal androgen exposure on the development of male-predominant neuropsychiatric disorders in female offspring of women with PCOS.
PMID: 30857571 [PubMed - as supplied by publisher]

Source: Psychological Medicine - March 11, 2019 Category: Psychiatry Authors: Cesta CE, Öberg AS, Ibrahimson A, Yusuf I, Larsson H, Almqvist C, D'Onofrio BM, Bulik CM, Fernández de la Cruz L, Mataix-Cols D, Landén M, Rosenqvist MA Tags: Psychol Med Source Type: research