Issue Cover (March 2019)

Front cover:Venlafaxine is a serotonin and norepinephrine reuptake inhibitor that is commonly prescribed for individuals who suffer from major depressive disorder. A full understanding of how venlafaxine improves function in responsive individuals is unknown. In the present study, we tested the possibility that venlafaxine could attenuate perineuronal net (PNN) integrity and concomitantly increase the power of hippocampal gamma oscillations in ex vivo slices. The PNN is thought to facilitate the activity of parvalbumin ‐expressing, GABA‐releasing interneurons. We therefore posit that in the background of PNN diminution, gamma power is enhanced through disinhibition of pyramidal cells.Image content: Shown is a section of murine hippocampus from a venlafaxine treated animal following immunostaining with an antibody to parvalbumin (red) and a perineuronal net binding lectin (green).Read the full article‘Venlafaxine stimulates PNN proteolysis and MMP ‐9‐dependent enhancement of gamma power; relevance to antidepressant efficacy’ by S. Alaiyed, P. L. Bozzeli, A. Caccavano, J. Y. Wu, K. Conant (J. Neurochem. 2019, vol. 148 (6), pp. 810 –821) on doi:10.1111/jnc.14671
Source: Journal of Neurochemistry - Category: Neuroscience Tags: Issue Cover Source Type: research