Linking Mn2+, {alpha}-synuclein, and neuroinflammation

Several studies elucidate the molecular links between manganese exposure and Parkinson’s disease.
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Editors ' Choice Source Type: news

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Condition:   Parkinson's Disease Interventions:   Device: Remote ischaemic conditioning;   Other: conventional therapy Sponsor:   General Hospital of Shenyang Military Region Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
TUESDAY, March 31, 2020 -- Thirty-six months of treatment with immediate-release isradipine does not slow clinical progression of early-stage Parkinson disease (PD), according to a study published online March 31 in the Annals of Internal...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
This study trial was registered in Chinese Clinical Trial Registry (No. ChiCTR1900022655). All the participants provided written informed consent. RESULTS After DBS surgery, all of study patients' symptoms were improved, with different levels of improvement. The minimum and maximum improvement rates were 20% and 100% respectively. The score of item 3.13 of the MDS-UPDRS III and the degree of camptocormia were found to be obviously improved (P
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 29 March 2020Source: Stem Cell ResearchAuthor(s): Muwan Chen, Muyesier Maimaitili, Susanne Hvolbøl Buchholdt, Uffe Birk Jensen, Fabia Febbraro, Mark Denham
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Conclusions: The severity of trunk misalignment does not fully explain limitation in ADLs, motor impairment, falls, and back pain. Multiple factors possibly related to an aggressive PD phenotype may account for disability in PD patients with FTB, LTB, and FNB.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Antioxidants&Redox Signaling, Ahead of Print.
Source: Antioxidants and Redox Signaling - Category: Research Authors: Source Type: research
Nature Reviews Neurology, Published online: 31 March 2020; doi:10.1038/s41582-020-0351-5Gene therapy boosts response to levodopa in patients with Parkinson disease
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
This study used an ultrasens itive methodology, fluorescence nanoparticle tracking analysis (NTA), to measure plasma L1CAM exosomes and Quanterix Simoa to measure α-syn concentrations in L1CAM exosomes. Eighty-five healthy controls and 93 PD patients were enrolled, and several scales were used to rate the severity of PD. Recei ver operating characteristic (ROC) curves were applied to map the diagnostic accuracy of categorizing PD patients and healthy subjects. We found increased Linc-POU3F3 and α-syn concentrations in L1CAM exosomes and decreased GCase activity in PD patients compared with controls. The three b...
Source: Neurotherapeutics - Category: Neurology Source Type: research
We present surface X-ray diffraction and fast scanning tunneling microscopy results to elucidate the nature of the surface phase transition on magnetite (001) from a ( √2 x √2) R45° reconstructed... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
Conditions:   Parkinson Disease;   Kinesiotaping Interventions:   Other: Kinesiotaping;   Other: Exercise Sponsor:   University of Castilla-La Mancha Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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