Individual culture and atmospheric oxygen during culture affect mouse preimplantation embryo metabolism and postimplantation development

ConclusionsPreimplantation metabolism of glucose and amino acids is altered by both oxygen and individual culture, and fetal weight is reduced by individual culture under atmospheric oxygen but not 5% oxygen. This study raises concerns regarding the increasing prevalence of single embryo culture in human IVF and adds to the existing evidence regarding the detrimental effects of atmospheric oxygen during embryo culture. Furthermore, these data demonstrate the cumulative nature of stress during embryo culture and highlight the importance of optimising each element of the culture system.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research