Effect of recombinant human vascular endothelial growth factor (VEGF-165) on testis tissue xenotransplants from prepubertal boys: A three-case study

ConclusionsIn vitro pre-treatment of human prepubertal testis tissue with VEGF improved transplant vascularisation in two out of three cases resulting in improved seminiferous tubule integrity and spermatogonial survival during xenotransplantation. Although further studies are warranted, we suggest VEGF be considered as a factor for improving the efficiency of immature testis tissue transplantation in a future clinical setting.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research