Synthesis of Deuterium Labeled 5, 5-Dimethyl-3-( α, α, α-trifluoro-4-nitro-m-tolyl) Hydantoin.

CONCLUSION: We successfully synthesized [2H6]-nilutamide and [2H6]-dimethylhydantoin with good isotopic purity, measured to be of adequate quality for use as internal standards in bio-analytical studies. A brief mechanistic study of Bucherer-Bergs hydantoin reaction was carried and the reason for possible H/D exchange was explained. PMID: 30854946 [PubMed - in process]
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research