Evaluation of polyphenolic profile and antibacterial activity of pomegranate juice in combination with rifampin (R) against MDR-TB clinical isolates.

CONCLUSION: Minimum inhibitory concentration (MIC) of FPJ for first group ranged from (4%-13%), while for second group and third group were approximately between (10%-15%). Thus, FPJ at 15% inhibited 100% of bacteria for all tested isolates (MIC100% =15%). Phenolic compounds identified in FPJ were gallic acid, benzoic acid, syringic, folic acid, pelargonidin, naringin+ellagic acid, naringenin, chlorogenic acid, caffeic acid, catechin, myricetin, Kaempferol, Quercetin, cyanidin-3-glycoside, p-cummaric acid, ferulic acid, and rutin. Total phenolic (TP), total flavonoid (TF), and total anthocyanin (TA) content were 841.5 mg /L, 638.73 mg RE/L, and 47.43 mg/L, accordingly. Overall, FPJ displayed synergetic effect with R against MDR-TB clinical isolates due to its high content of polyphenol and antioxidant capability. PMID: 30854955 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research