Smith and Nephew expands in high growth regenerative medicine market through acquisition of Osiris Therapeutics, Inc.

LONDON, March 12, 2019 -- (Healthcare Sales &Marketing Network) -- Smith &Nephew plc (LSE: SN,NYSE: SNN), the global medical technology business, announces that it has agreed to acquire Osiris Therapeutics, Inc. (NASDAQ: OSIR), a fast growing company de... Devices, Orthopaedic, Mergers &Acquisitions Smith &Nephew, Osiris Therapeutics, dermal graft, bone graft
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

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The development of biomaterials for orthopedic applications is a crowded space with several large and small companies designing innovative materials. One approach is the use of these materials to deliver therapeutic proteins that enhance healing. The...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Nanomedicine Orthopedic Surgery Source Type: blogs
Condition:   Chronic Allograft Injury Interventions:   Drug: UCB7858;   Drug: Placebo Sponsor:   UCB Biopharma SRL Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: The combination of PRF plus bone filler promotes bone neoformation, increased trabecular bones, and improved healing times; however, after 6 months of monitoring, the results were not significantly different with the groups that did not use the PRF in the procedure of maxillary sinus floor lift with lateral window technique. Regarding the preservation of alveolar ridge the different studies are not conclusive: some indicate that the mixture of a concentrate with a bone filling seems to improve the volumetric proportions; however, other studies report bone loss in width and even greater degree of inflammation.
Source: Revista Espanola de Cirugia Oral y Maxilofacial - Category: ENT & OMF Source Type: research
Immunotherapy, Ahead of Print.
Source: Immunotherapy - Category: Allergy & Immunology Authors: Source Type: research
In this study, the clinical outcomes of horizontal ridge augmentation using half-columnar bone grafts from the ramus (group I: 27 patients, 32 implants) versus rectangular bone grafts from the symphysis (group II: 19 patients, 27 implants) were compared; grafts were combined with organic bovine bone and collagen membrane. Cone beam computed tomography images were obtained preoperatively, immediately after restoration (baseline), and 1 year after loading. Four months after grafting, horizontal bone resorption at the alveolar crest did not differ significantly between the two groups (P=0.291).
Source: International Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Randomised Clinical Trial, Pre-Implant Surgery Source Type: research
Background: Following transplant, cancer is a leading cause of morbidity and mortality. Human leukocyte antigen-G (HLA-G) – an immune checkpoint molecule – reduces allograft rejection by dampening host immune responses. Reports suggest malignant cells utilize HLA-G to evade the immune system and promote cancer development. Our objective was to evaluate HLA-G donor-recipient polymorphism matching and development of cancer following heart transplant. Methods: Recipients (n=251) and corresponding donors (n=196) were genotyped retrospectively to identify HLA-G polymorphisms in the 5’regulatory (–725, &n...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Authors: Schaefer B, Beier JP, Ruhl T Abstract Skeletal muscle represents the largest mass of tissue in the body and is essential for motion and posture. Traumatic injury, tumor ablation, prolonged denervation or genetic defects lead to skeletal myopathies. The loss of muscle function or its regenerative properties often results in pain, deformity, and joint malfunction. The regenerative capacity of skeletal muscles depends on adult muscle stem cells, the so-called satellite cells; however, the population of these myogenic precursors, and thus their potential to restore large muscle tissue defects, is strongly limi...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
ConclusionsAlthough the aetiology of SONK remains unknown, there are many treatment options, and the choice of the most suitable one is challenging. We think that subchondroplasty may be one of the effective methods.
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
Takigawa Kuniaki Okamoto Matrix metalloproteinase 3 (MMP3) plays multiple roles in extracellular proteolysis as well as intracellular transcription, prompting a new definition of moonlighting metalloproteinase (MMP), according to a definition of protein moonlighting (or gene sharing), a phenomenon by which a protein can perform more than one function. Indeed, connective tissue growth factor (CTGF, aka cellular communication network factor 2 (CCN2)) is transcriptionally induced as well as cleaved by MMP3. Moreover, several members of the MMP family have been found within tumor-derived extracellular vesicles (EVs). We...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Ovcharenko N, Greenwell H, Katwal D, Patel A, Hill M, Shumway B, Cockerham BL Abstract Twenty patients completed this randomized, controlled, blinded clinical trial comparing ridge preservation with a bioabsorbable polylactic acid membrane (PLA group) compared to an acellular dermal matrix membrane guided bone regeneration (ADMG group). An intrasocket corticocancellous allograft plus a facial overlay xenograft was used for both groups. Final crestal ridge width was significantly greater for the ADMG group (P
Source: International Journal of Periodontics and Restorative Dentistry - Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research
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