Adeno-associated virus 9-mediated small RNA interference of TLR4 alleviates myocardial ischemia and reperfusion injury by inhibition of the NF- κB and MAPK signaling pathways in rats.

Conclusion AAV9-TLR4 siRNA has a positive effect on myocardial I/R injury by inhibiting the MAPK and NF-κB signaling pathways and can be used as a potential therapeutic method for myocardial I/R injury.
PMID: 30854968 [PubMed - as supplied by publisher]

Source: Current Molecular Medicine - March 10, 2019 Category: Molecular Biology Authors: Xu T, Zhang K, Kan F, Li F, Yu B, Du W, Nie H Tags: Curr Mol Med Source Type: research