Haploidentical HSCT with post-transplant CY for primary immunodeficiencies and inherited disorders in children
Allogenic hematopoietic stem cell transplantation (HSCT) is a treatment option for children with various malignant or non-malignant diseases, including selected primary immunodeficiencies (PIDs) and inherited disorders. A graft from a healthy, HLA-genoidentical, matched sibling donor is the best option but is available in fewer than 25% of cases. Less than 70% of the remaining patients will have a suitable matched unrelated donor, a proportion that is even lower for patients belonging to ethnic groups poorly represented in donor registries [1].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: B énédicte Neven, Jean-Sébastien Diana, Martin Castelle, Alessandra Magnani, Jérémie Rosain, Fabien Touzot, Baptiste Moreira, Marie-Louise Fremond, Coralie Briand, Matthieu Bendavid, Levy Romain, Morelle Guillaume, Marc Vincent, Elsa Magrin, Philippe Source Type: research
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