DNA methylation genome-wide analysis in remnant and primary gastric cancers

ConclusionsThis study demonstrated that promoter methylation status in PGC is higher than in RGC. This result may reflect the effects of the absence ofHelicobacter pylori on the reduced DNA methylation in the remnant stomach.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research

Related Links:

Conclusions: These results indicate that sulglycotide could be an anti-inflammatory and anti-oxidative compound that may be a useful candidate for treatment of inflammatory diseases. PMID: 31232125 [PubMed - as supplied by publisher]
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
We describe a case of a patient treated for cognitive dysfunction (CD) with suspected thiamine deficiency (TD). A 74-year-old man with gastric cancer presented with grade 3 diarrhea and grade 1 anorexia. He had been receiving trastuzumab plus tegafur (a chemotherapeutic fluorouracil prodrug), gimeracil, and oteracil (S-1) and oxaliplatin. On admission, cognitive function was assessed with the Hasegawa's Dementia Scale (HDS-R) because he had impaired short-term memory. His thiamine levels increased from 22 to 109 ng/mL after administration of 75 mg of thiamine. Furthermore, the patient's HDS-R score improved from 9 to 22, a...
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
In conclusions, the present study identified a novel six-DMGs prognostic signature that could serve as a biomarker for the prognosis prediction of patients with gastric cancer.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conclusion: In this retrospective study, 0.5% (6/1179) of lung cancer patients were found to harbor a germline mutation on MSH2, MSH6 or PMS2. However, two of these patients displayed intact MMR protein expression, MSS and TMB-L. Combined with the baseline characteristics of 6 patients, it seems that lung cancers may not be related to Lynch syndrome. Relationships between the development of lung cancers and Lynch syndrome still requires further large–scale investigations. Nonetheless paired tumor–normal next-generation sequencing can identify germline mutations including that related with Lynch syndrome in canc...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In this study, the in vitro proliferation inhibition effect of SAN in GC cells was determined using CCK-8 assay, the in vivo antitumor effect of SAN was evaluated in mice with xenotransplanted tumor. The mechanism underlying the antitumor activity of SAN was explored by gene microarray assay and bioinformatics analysis. The levels of differentially expressed miRNAs and target genes were verified by real-time RT-PCR and immunohistochemistry. SAN inhibited the proliferation of BGC-823 cells in a concentration-dependent manner in vitro and in vivo. The miR-96-5p and miR-29c-3p were significantly upregulated in untreated BGC-8...
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research
An altered oral microbiota has been linked with the development of several oral diseases, such as dental caries, periodontal disease, and oral stomatitis. Moreover, poor oral health has been linked to head and neck cancer, particularly oral cancer. In recent years a growing number of studies indicate that oral microbiota could be involved in the development of primary tumours outside of head and neck region. The aim of this article is to review the recent studies based on high-throughput technology to present evidences of a relationship between oral microbiota and “non-head and neck tumours”. Oral dysbiosis see...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Thomas A. Abrams Senior Physician and Assistant Professor of Medicine at Harvard Medical School tells us histhoughts on KEYNOTE-62. This is investigating pembrolizumab in HER2, PD-L1 positive advanc... Author: obr Added: 06/25/2019
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
This study provides an important and necessary summary of the current data, enabling clinicians to better inform patients of the associated short and long-term outcomes in risk-reducing surgery for cancer predisposition genes.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conditions:   Clinical Stage 0 Gastric Cancer AJCC v8;   Clinical Stage I Gastric Cancer AJCC v8;   Clinical Stage II Gastric Cancer AJCC v8;   Clinical Stage IIA Gastric Cancer AJCC v8;   Clinical Stage IIB Gastric Cancer AJCC v8;   Clinical Stage III Gastric Cancer AJ CC v8;   Gastric Adenocarcinoma;   Pathologic Stage 0 Gastric Cancer AJCC v8;   Pathologic Sta...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Listen to critics of the Wheat Belly lifestyle and you’d think that, by banishing all things wheat and grains from your life, you will be excommunicated from your church, tossed out of your club, ostracized by friends and family, and suffer dire health consequences like heart disease and colon cancer. After all, they say that you are eliminating an entire food group and will be crippled by lack of fiber and nutrients. Worse, our focus on increasing our intake of fats and oils will get you a heart attack, three stents, or bypass surgery and you’ll be obliged to take Lipitor and Repatha for a lifetime. First of a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle grain-free Weight Loss Source Type: blogs
More News: Cancer | Cancer & Oncology | Gastric (Stomach) Cancer | Gastroenterology | Genetics | Study | Training | Universities & Medical Training