Correlations between imaging biomarkers and proliferation index Ki 67 in lymphomas – A systematic review and meta analysis

Publication date: Available online 11 March 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Hans-Jonas Meyer, Andreas Wienke, Alexey SurovAbstractFew studies investigated relationships between positron emission tomography (PET) as well as Diffusion-weighted imaging (DWI) with proliferating index Ki 67 in lymphomas. The aim of the present analysis was to review the published results and perform a meta analysis to provide data of the associations between standardized uptake values (SUV) derived from PET as well as apparent diffusion coefficients (ADC) derived from DWI with Ki 67 index in lymphomas. MEDLINE library was screened for relationships between PET and DWI with Ki 67 in lymphomas up to October 2018. Overall, 22 studies with 788 patients were identified. The following data were extracted from the literature: authors, year of publication, number of patients, and correlation coefficients. Associations between SUV and Ki 67 were analyzed by Spearman's correlation coefficient. 15 studies comprising 574 patients were suitable for the analysis between SUVmax derived from FDG PET and Ki 67. The pooled correlation coefficient was r=0.49 [95% CI 0.36-0.61]. 4 studies included into the analysis between SUVmax derived from FLT PET and Ki 67 index involving 84 patients. The pooled correlation coefficient was r=0.46 [95% CI 0.19-0.73]. 4 studies comprising 130 patients were suitable for the analysis between ADC values derived from DWI and Ki67. The pooled correlation coe...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research