Sildenafil: Time to Look Beyond Pulmonary Pressures

IN THIS ISSUE of the journal, Ram et al.1 report on their study on the effects of postoperative sildenafil in patients with pulmonary hypertension undergoing mitral valve surgery. This expands on previous work done in postoperative patients with pulmonary hypertension, including the study by Jiang et al.,2 in which a single, larger dose of sildenafil was used postoperatively in 90 adult patients, and a study by Raja et al.,3 who examined a dose range of 0.5 to 2 mg/kg in 10 pediatric patients who also were on nitric oxide.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research