Immunodeficiency and Epstein Barr virus induced lymphoproliferation caused by 4-1BB deficiency

We have identified a novel immunodeficiency associated with EBV induced lymphoproliferation due to a homozygous missense mutation in 4-1BB, demonstrating a critical role for 4-1BB in the human immune response against EBV-driven B cell lymphoproliferation.

Source: Journal of Allergy and Clinical Immunology - March 10, 2019 Category: Allergy & Immunology Authors: Mohammed Alosaimi, Manfred Hoenig, Faris Jaber, Craig D. Platt, Jennifer Jones, Jacqueline Wallace, Klaus-Michael Debatin, Ansgar Schulz, Eva Jacobsen, Peter M öller, Hanan E. Shamseldin., Ferdous Abdulwahab, Niema Ibrahim, Hosam Alardati, Faisal Almuhiz Source Type: research