Mast cell-mediated splanchnic cholestatic inflammation.

CONCLUSIONS: In cholestatic rats, Ketotifen improves liver function and ascites, and also reduces pro-inflammatory mediators in the splanchnic area. The decrease in connective tissue mast cells in the mesenteric lymphatic complex due to the administration of Ketotifen would lead to the improvement of the inflammatory splanchnic response, and consequently the abovementioned complications.
PMID: 30853494 [PubMed - as supplied by publisher]

Source: Clin Med Res - March 6, 2019 Category: Research Authors: Aller MÁ, Martínez V, Arias A, Nava MP, Cuervas-Mons V, Vergara P, Arias J Tags: Clin Res Hepatol Gastroenterol Source Type: research