Retinal Nerve Fiber Layer Thickness Decrease in Obesity as a Marker of Neurodegeneration

This study included 111 eyes from 36 obese patients (86% female, body mass index>  35 kg/m2) scheduled to bariatric surgery and 20 non-obese (body mass index
Source: Obesity Surgery - Category: Surgery Source Type: research

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AbstractBackgroundSingle anastomosis sleeve ileal (SASI) bypass is a newly introduced bariatric and metabolic procedure. The present multicenter study aimed to evaluate the efficacy of the SASI bypass in the treatment of patients with morbid obesity and the metabolic syndrome.MethodsThis is a retrospective, seven-country, multicenter study on patients with morbid obesity who underwent the SASI bypass. Data regarding patients ’ demographics, body mass index (BMI), percentage of total weight loss (%TWL), percentage of excess weight loss (%EWL), and improvement in comorbidities at 12 months postoperatively and postopera...
Source: Obesity Surgery - Category: Surgery Source Type: research
sti R Abstract Protein carbonylation is a marker of oxidative protein damage, that is likely involved in the pathogenesis of several diseases. The aim of this study was to evaluate the protein carbonyl (PC) groups in different clinical conditions. It included different groups of subjects: 81 trained subjects; 23 subjects with mild essential hypertension; 31 middle-aged subjects with metabolic syndrome (MS); 106 subjects with MS not selected for age (subdivided into two subgroups, with and without diabetes mellitus); 91 obese adults subdivided in two subgroups (BMI 30-35 Kg/m2 and BMI > 35 kg/m2); 48 subject...
Source: Clinical Hemorheology and Microcirculation - Category: Hematology Authors: Tags: Clin Hemorheol Microcirc Source Type: research
ConclusionThese data enhance the search for SAS by sleep recording that must be proposed in patients with obesity and a treatment-resistant HT since its management makes possible the improvement of the blood pressure profile and may prevent cardiovascular complications.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Bariatric surgery is known to have positive effects on various aspects of metabolic syndrome and weight-related comorbidities [1 –6]. The current body mass index (BMI) recommendation cutoff of 35kg/m2 for bariatric surgery was established in 1991 by the National Institutes of Health consensus guidelines [7]. Meanwhile, incidence of obesity and its associated chronic illnesses, such as hypertension, diabetes, sleep apnea, et c, continue to increase [8]. An increasing portion of the population is categorized as having class I obesity (defined as BMI ≥30 and
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Originial Article Source Type: research
Conclusions: Severe OSA is independently associated with increased liver stiffness which may predispose OSA patients to a higher risk of liver fibrosis.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
Conclusion: Blacks with MetS reported insomnia symptoms and insomnia disorder, use of sleep aids, feeling sleepy during the day, and inadequate sleep durations. The presence of these sleep characteristics suggests that patients with MetS should be referred for further sleep assessment. PMID: 30038481 [PubMed - in process]
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
ConclusionsThe findings of this pilot study suggest that increased lipid peroxidation is associated with insulin resistance and hypertension in obese children and adolescents, while OSA has most likely minor influence.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
CONCLUSIONS: The findings of this pilot study suggest that increased lipid peroxidation is associated with insulin resistance and hypertension in obese children and adolescents, while OSA has most likely minor influence. PMID: 29804216 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
Abstract Resistant hypertension is defined as high blood pressure that remains uncontrolled despite treatment with at least three antihypertensive drugs at adequate doses. Resistant hypertension is an increasingly common clinical problem in older age, obesity, diabetes, sleep apnea, and chronic kidney disease. Although the direct vasodilator minoxidil was introduced in the early 1970s, only recently has this drug been shown to be particularly effective in a subgroup of patients with treatment‐resistant or uncontrolled hypertension. This pharmacological approach is interesting from a mechanistic perspective as minoxidil i...
Source: Microcirculation - Category: Research Authors: Tags: INVITED REVIEW Source Type: research
The metabolic syndrome —otherwise called syndrome X, insulin resistance syndrome, Reaven syndrome, and “the deadly quartet”—is the name given to the aggregate of clinical conditions comprising central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dy slipidemia. It is a prothrombotic and proinflammatory state characterized by increased inflammatory cytokine activity. In addition to inflammatory dermatoses such as psoriasis, lichen planus, and hidradenitis suppurativa, metabolic syndrome is also commonly associated with accelerated athe...
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research
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