Calcium imaging approaches in investigation of pain mechanism in the spinal cord.

Calcium imaging approaches in investigation of pain mechanism in the spinal cord. Exp Neurol. 2019 Mar 07;: Authors: Xu Q, Dong X Abstract The continuous advancement of microscopic imaging techniques combined with the discovery and use of more powerful calcium indicators has made calcium imaging technology much more effective and has increased its use in the study of pain circuitry. Using calcium imaging to study spinal pain mechanisms causes less damage to animals compared to electrophysiological techniques and is also able to observe the firing pattern of spinal neurons and the connections between them on a large scale. These advantages allow any changes in spinal cord circuits caused by pain transmission to be observed more effectively. This review will discuss the development of calcium indicators over the past decades as well as the various applications of calcium imaging, from in vitro to in vivo spinal cord experiments, in the study of pain circuits. We will also discuss possible directions for the study of spinal pain circuits in the future. PMID: 30853387 [PubMed - as supplied by publisher]
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

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Authors: Andrade RR, Oliveira-Neto OB, Barbosa LT, Santos IO, Sousa-Rodrigues CF, Barbosa FT Abstract BACKGROUND AND OBJECTIVES: Low back pain is a prevalent disease in the adult population, whose quality of life is considerably affected. In order to solve this problem, several therapies have been developed, of which ozone therapy is an example. Our objective in this study was to determine the effectiveness of ozone therapy for lumbar pain relief in adult patients compared to other therapies (steroid and placebo). METHOD: We usused randomized clinical trials to compare the effectiveness of ozone and other thera...
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
Back in May, Bruce Schoneboom wrapped up his appointment to the HHS Pain Management Best Practices Inter-Agency Task Force. The group determined best practices for managing chronic and acute pain—and addressed judicious prescribing of opioids. If you didn’t know: The CDC reports there are 192 overdose deaths in the U.S. every day. Forty percent of The post Dr. Bruce Schoneboom and the HHS Pain Task Force appeared first on Johns Hopkins Nursing Magazine.
Source: Nursing Blogs at Johns Hopkins University - Category: Nursing Authors: Tags: New On the Pulse DNP nurse anesthesiology nurse anesthetist pain month Source Type: blogs
Conclusions The authors conclude that sympathetic blocks may be therapeutic in patients with complex regional pain syndrome regardless of preprocedure limb temperatures. The effects of sympathetic blocks do not predict the success of spinal cord stimulation.
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Between work commitments, family obligations and social events, it may seem daunting — and downright impossible — to add anything else to your plate. As a result, people tend to sacrifice the one thing they might enjoy doing the least — exercise. Perhaps it started with a busy week, and then one week turned into two and then before you knew it, you hadn’t visited the gym in a series of months. Whatever the culprit, there are ways to pull yourself out of a workout rut and create a lasting routine. Here, health and wellness experts provide five strategies that will get you back on track. Find your ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Exercise fitness Workout Source Type: news
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Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Emotion Feature Positive psychology The self Source Type: blogs
The FDA recently approved the first generics of pregabalin for managing fibromyalgia, postherpetic neuralgia, neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, and as adjunct therapy for partial-onset seizures in patients aged 17 years or older.
Source: JAMA - Category: General Medicine Source Type: research
Authors: Hao J, Dong B, Zhang J, Luo Z Abstract OBJECTIVES:   To evaluate whether pre-emptive analgesia is an effective technique to reduce postoperative delirium (PD) in geriatric patients with hip fracture. METHODS: This is a double-blind randomized clinical trial. Ninety elderly patients scheduled for hipfracture surgery at HongHui Hospital, Xi'an Jiaotong University, Xi'an, China  between March 2018 and January 2019 were divided into 2 groups. On arrival at the emergency department, the experimental group (n=44) received ultrasound-guided continuous fascia iliaca compartment block (...
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Conditions:   Headache Disorders, Secondary;   Post-Dural Puncture Headache;   Migraine Disorders;   Back Pain;   Anesthesia Intervention:   Sponsor:   Stanford University Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Low Back Pain Interventions:   Other: Dry needling in hamstring muscle trigger points;   Other: Dry needling in hamstring muscle not trigger points Sponsor:   University of Alcala Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Headache Disorders, Secondary;   Post-Dural Puncture Headache;   Migraine Disorders;   Back Pain;   Anesthesia Intervention:   Sponsor:   Stanford University Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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