Performance of creatinine- or cystatin C –based equations to estimate glomerular filtration rate in sub-Saharan African populations

Glomerular filtration rate (GFR) is the best index for kidney function; however, the applicability of GFR estimating equations in sub-Saharan African populations remains unclear. In a cross-sectional study of adults living in Kinshasa, Democratic Republic of Congo (n=210) and Abidjan, Ivory Coast (n=284), we evaluated the performance of creatinine and cystatin C –based equations using plasma clearance of iohexol as the reference standard. The race coefficient did not improve the performance of creatinine-based GFR estimates; in fact, both the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology (CKD-EPI) equations performed better without the race coefficient in participants with GFR ≥60 mL/min/1.73m2.

Source: Kidney International - March 10, 2019 Category: Urology & Nephrology Authors: Justine B. Bukabau, Eric Yayo, Appolinaire Gnionsah é, Dagui Monnet, Hans Pottel, Etienne Cavalier, Aliocha Nkodila, Jean Robert R. Makulo, Vieux M. Mokoli, François B. Lepira, Nazaire M. Nseka, Jean-Marie Krzesinski, Ernest K. Sumaili, Pierre Delanaye Tags: Clinical Investigation Source Type: research