Protection from Zika virus may lie in a protein derived from mosquitoes

By targeting a protein found in the saliva of mosquitoes that transmit Zika, Yale investigators reduced infection in mice, offering new hope for a vaccine.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

Related Links:

(University of Queensland) Scientists looking at the genetics of Zika virus have found a way to fast-track research which could lead to new vaccines.The study, led by The University of Queensland and QIMR Berghofer Medical Research Institute, used a new technique to uncover Zika mutations that help foster virus replication in mosquito hosts, while hindering its ability to replicate in mammals.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Publication date: April 2019Source: Current Opinion in Virology, Volume 35Author(s): Jing Zou, Pei-Yong ShiZika virus (ZIKV) can cause devastating congenital syndrome in fetuses from pregnant women and autoimmune disorder Guillain-Barré syndrome in adults. No clinically approved vaccine or drug is currently available for ZIKV. This unmet medical need has motivated a global effort to develop countermeasures. Several promising ZIKV vaccine candidates have already entered clinical trials. In contrast, antiviral development of ZIKV is lagging behind. Here, we review the overall strategies for ZIKV drug discovery, includ...
Source: Current Opinion in Virology - Category: Virology Source Type: research
The flu season is up and running in the Northern Hemisphere, and early signs in both the United States and Europe are that the effects might not be quite as severe as the brutal 2017/18 season. The United States is predominantly seeing H1N1 circulating, while monitoring in Europe has identified co-circulation of H1N1 and H3N2—both varieties of Influenza A that should be covered by the seasonable vaccine. What if they weren’t though? Influenza A can be found in both human and animal populations, and it evolves rapidly through genetic mutation. Each year many humans rely on their country&a...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
by Kenneth Dinnon, Emily Gallichotte, Ethan Fritch, Vineet Menachery, Ralph Baric Zika virus (ZIKV) is a mosquito-borne positive sense RNA virus. Recently, ZIKV emerged into the Western hemisphere as a human health threat, with severe disease associated with developmental and neurological complications. The structural envelope protein of ZIKV and other neurotropic flaviviruses contains an extended CD-loop relative to non-neurotropic flaviviruses, and has been shown to augment ZIKV stability and pathogenesis. Here we show that shortening the CD-loop in ZIKV attenuates the virus in mice, by reducing the ability to invade an...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
by Oliver J. Brady, Aaron Osgood-Zimmerman, Nicholas J. Kassebaum, Sarah E. Ray, Valdelaine E. M. de Ara újo, Aglaêr A. da Nóbrega, Livia C. V. Frutuoso, Roberto C. R. Lecca, Antony Stevens, Bruno Zoca de Oliveira, José M. de Lima Jr., Isaac I. Bogoch, Philippe Mayaud, Thomas Jaenisch, Ali H. Mokdad, Christopher J. L. Murray, Simon I. Hay, Robert C. Reiner Jr., Fatima Marinho BackgroundIn 2015, high rates of microcephaly were reported in Northeast Brazil following the first South American Zika virus (ZIKV) outbreak. Reported microcephaly rates in other Zika-affected areas were significantly lower...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Jacobs Robin Ketteler Marcus Dorner Mark Marsh Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific antagonists can be made available. Broad-spectrum antivirals are drugs with the potential to inhibit infection by viruses from different groups or families, which may be deployed during outbreaks when specific diagnostics, vaccines or directly acting antivirals are not available. While pathogen-directed approaches are generally effective against ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In conclusion, at time points after PCR can detect the virus, the determination of anti-ZIKV NS1 IgA may improve the accuracy in diagnosing acute ZIKV infection in flavivirus-endemic regions in the context of both primary and secondary infection, especially when IgM is undetectable. PMID: 30779938 [PubMed - as supplied by publisher]
Source: Journal of Virological Methods - Category: Virology Authors: Tags: J Virol Methods Source Type: research
In this study we established a competitive amplified luminescent proximity homogeneous assay (ALPHAscreen) to identify small molecule inhibitors targeting the envelope protein of Zika virus (Zika E). We utilized this assay to screen two libraries of nearly 27,000 compounds and identified seven novel inhibitors of Zika E. Characterization of these primary screening leads demonstrated that inhibition of Zika virus occurs at non-cytotoxic concentrations for all seven lead compounds. In addition, we found that all seven lead compounds have potent activity against the closely related dengue virus 2 but not vesicular stomatitis ...
Source: Antiviral Therapy - Category: Virology Source Type: research
In this study we established a competitive amplified luminescent proximity homogeneous assay (ALPHAscreen) to identify small molecule inhibitors targeting the envelope protein of Zika virus (Zika E). We utilized this assay to screen two libraries of nearly 27,000 compounds and identified seven novel inhibitors of Zika E. Characterization of these primary screening leads demonstrated that inhibition of Zika virus occurs at non-cytotoxic concentrations for all seven lead compounds. In addition, we found that all seven lead compounds have potent activity against the closely related dengue virus 2 but not vesicular stomatitis ...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Publication date: Available online 10 February 2019Source: Antiviral ResearchAuthor(s): Elaine M. Morazzani, Jaimee R. Compton, Dagmar H. Leary, Angela V. Berry, Xin Hu, Juan Marugan, Pamela J. Glass, Patricia M. LeglerAbstractThe alphaviral nonstructural protein 2 (nsP2) cysteine proteases (EC 3.4.22.-) are essential for the proteolytic processing of the nonstructural (ns) polyprotein and are validated drug targets. A common secondary role of these proteases is to antagonize the effects of interferon (IFN). After delineating the cleavage site motif of the Venezuelan equine encephalitis virus (VEEV) nsP2 cysteine protease,...
Source: Antiviral Therapy - Category: Virology Source Type: research
More News: Science | Universities & Medical Training | Vaccines | Yale | Zika Virus