Can pretreatment 18 F-FDG PET tumor texture features predict the outcomes of osteosarcoma treated by neoadjuvant chemotherapy?

ConclusionsIntratumoral heterogeneity of baseline18F-FDG uptake measured by PET texture analysis can predict tumor response and EFS of patients with extremity osteosarcoma treated by NAC, but the conventional parameter MTV provides better predictive power and is a strong independent prognostic factor.Key Points• The baseline18F-FDG PET tumor texture features can predict tumor NAC response for patients with osteosarcoma.• CoarsenessNGTDMis a new and independent prognostic factor for osteosarcoma.• MTV provides the best predictive power and is a strong independent prognostic factor for patients with osteosarcoma.
Source: European Radiology - Category: Radiology Source Type: research