Global 'pandemic' of fake drugs killing children worldwide, report says

The deaths of children are a cause for misery, and new research suggests one of the gravest perils comes in the form of falsified and substandard drugs for treating malaria, pneumonia and other diseases. Hundreds of thousands of children each year are dying due to a surge of poor-quality or outright fake medicines, the report says.
Source: - Health - Category: Consumer Health News Source Type: news

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[Daily Trust] Malam Umar Aminu-Imam, President, Environmental Health Officers Association of Nigeria (EHOAN) in Katsina State, has said that 13,687,500 Nigerians battled with malaria annually.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Authors: Ndong Ngomo JM, Amiah Ahou M, Yavo W, Karine Bouyou-Akotet M, Mawili-Mboumba DP Abstract The aim of this study was to assess the proportion of Pfcrt-76T mutant allele four years after the adoption of new malaria control guidelines in Gabon and Ivory Coast. Frequency of K76T mutation of Pfcrt gene was compared between Plasmodium falciparum isolates from Gabon and Ivory Coast. Samples were collected in 2008 in Gabon and in 2009 in Ivory Coast. In total, 151 isolates were selected and analysed by nested-PCR-RFLP for Pfcrt-76 allele identification: 63 in Abobo (Ivory Coast) and 78 in Oyem (Gabon). The proporti...
Source: Bulletin de la Societe de Pathologie Exotique - Category: Tropical Medicine Tags: Bull Soc Pathol Exot Source Type: research
This study is nested within a randomised controlled trial investigating LAIV–microbiome interactions (NCT02972957).FindingsBetween Feb 8, 2017, and April 12, 2017, 118 children were enrolled and received one dose of the Cal09 LAIV from 2016–17. Between Jan 15, 2018, and March 28, 2018, a separate cohort of 135 children were enrolled and received one dose of the NY15 LAIV from 2017–18, of whom 126 children completed the study. Cal09 showed impaired pH1N1 nasopharyngeal shedding (16 of 118 children [14%, 95% CI 8·0–21·1] with shedding at day 2 after administration of LAIV) compared with ...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
ConclusionIn SLE cases, IP primarily occurred in male and elderly patients. In addition to the NSIP pattern, the UIP pattern was evident on HRCT scans of IP-related SLE. The survival of SLE patients was unrelated to IP.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Authors: Fanta Yadang SA, Taiwe Sotoing G, Ngatcha Zouakeu KS, Khan MA, Agbor GA, Ur-Rahman N, Ngo Bum E Abstract Carissa edulis is a plant used in the management of oxidative stress and inflammatory related disorders such as malaria, rheumatism inflammation, and cardiovascular diseases. The present study evaluates the total phenolic content, antioxidant capacity (DPPH, ABTS, and FRAP), and the bioactive compounds present in the various extracts of C. edulis (HEC, MEC, AEC, and PC). An HPLC analysis determined the different compounds present in the extracts. High concentration of total phenolic content was observed...
Source: The Scientific World Journal - Category: Science Tags: ScientificWorldJournal Source Type: research
Authors: Ricotta E, Kwan J Abstract The global spread of artemisinin resistance brings with it the threat of incurable malaria. Already, this disease threatens over 219 million lives per year and causes 5-6% losses in GDP in endemic areas, even with current advances in prevention and treatment. This chapter discusses the currently tenuous position we are in globally, and the impact that could be seen if artemisinin treatment is lost, whether due to the unchecked spread of K13 mutations or poor global investment in treatment and prevention advances. Artemisinin is the backbone of current ACT treatment programs and s...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
Authors: Adalja A, Inglesby T PMID: 31216912 [PubMed - as supplied by publisher]
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Abstract The amoeba-resistant bacterium Legionella pneumophila infects humans through aerosols and thereby can cause a life-threatening pneumonia termed Legionnaires' disease. In the environment L. pneumophila forms and colonizes biofilms, which usually comprise complex multispecies communities. In these biofilms L. pneumophila persists and replicates intracellularly in protozoa, such as the amoeba Acanthamoeba castellanii. The interactions between sessile L. pneumophila in biofilms and their natural protozoan hosts are not understood on a molecular level. Here, we describe a method to visualize by confocal m...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Publication date: Available online 21 June 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Karissa Culbreath, Suzanne Melanson, James Gale, Justin Baker, Fan Li, Oystein Saebo, Oyvind Kommedal, Deisy Contreras, Omai B. Garner, Shangxin YangNext-generation sequencing–based 16S rRNA gene metagenomic sequencing (16S MG) technology has tremendous potential for improving diagnosis of bacterial infections given its quantitative capability and culture-independent approach. We validated and utilized a quantitative 16S MG assay to identify and quantify bacterial species in clinical samples from a wide spectrum of i...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Source Type: news
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