Targeting C-fibers for peripheral acting anti-tussive drugs

Publication date: Available online 11 March 2019Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Mayur J. Patil, Hui Sun, Fei Ru, Sonya Meeker, Bradley J. UndemAbstractActivation of vagal C-fibers is likely involved in some types of pathological coughing, especially coughing that is associated with airway inflammation. This is because stimulation of vagal C-fibers leads to strong urge to cough sensations, and because C-fiber terminals can be strongly activated by mediators associated with airway inflammation. The most direct manner in which a given mediator can activate a C-fiber terminal is through interacting with its receptor expressed in the terminal membrane. The agonist-receptor interaction then must lead to the opening (or potentially closing) of ion channels that lead to a membrane depolarization. This depolarization is referred to as a generator potential. If, and only if, the generator potential reaches the voltage necessary to activate voltage-gated sodium channels, action potentials are initiated and conducted to the central terminals within the CNS. Therefore, there are three target areas to block the inflammatory mediator induced activation of C-fiber terminals. First, at the level of the mediator-receptor interaction, secondly at the level of the generator potential, and third at the level of the voltage-gated sodium channels. Here we provide a brief overview of each of these therapeutic strategies.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized China onetime Source Type: news
ConclusionIt is envisaged that the current review will add value to more scientific research on M. flabellifolius and enhance/promote the increased interest in the sustainable commercialization of M. flabellifolius herbal tea as well as lead to the validation of unverified ethnobotanical claims.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Acute cardiogenic pulmonary oedema (ACPO) is one of the common causes of acute respiratory failure, constituting 10% –20% of acute heart failure syndromes and potentially causing death [1]. Acute cardiogenic pulmonary oedema ACPO usually presents with sudden dyspnoea at rest, impaired exertion capacity, tachypnoea, tachycardia and hypoxia. Increased endogenous catecholamine levels and hypertension due to stress are common in cases with good left ventricular function. Cough is a frequent finding in these cases.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
ConclusionsThe SAPB, as part of a multimodal analgesia regimen, is non ‐inferior in terms of 48‐hour opioid consumption compared to SPVB and is associated with improved functional measures in thoracic surgical patients.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Condition:   Asthma Intervention:   Sponsor:   McMaster University Recruiting
Source: - Category: Research Source Type: clinical trials
Scientists behind the study, at the University of New South Wales, say new vaccines must be developed in the next five to 10 years to avoid bordetella pertussis morphing into a superbug.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusion Anlotinib effectively controlled the growth of NSCLC and improved TAO related symptoms. Anlotinib maybe normalize disordered growth of blood vessels through the VEGF signaling pathway, rather than simply inhibiting angiogenesis. 
 DOI: 10.3779/j.issn.1009-3419.2020.01.10
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
HUDSON (CBS) – The sick calls are pouring in at Mulready Elementary School in Hudson. The school has had dozens of absences in the past few days with all signs pointing to the flu. “This flu season has been incredibly busy,” said Dr. Mallika Marshall. She says urgent care centers have been inundated with patients. “Chances are it’s going to be one of the busiest flu seasons we’ve seen in recent years,” Dr. Marshall said. This week at Mulready started with around 90 absences. By Wednesday, 123 kids stayed home. About 40% of the school. On Thursday, 114 students were absent. &ldquo...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated CBSN Boston Syndicated Local Watch Listen Dr. Mallika Marshall Flu Hudson News Nick Emmons Source Type: news
A 4-year-old boy presented with facial swelling and respiratory distress of 3-day duration. Mild cough and rhinorrhea were reported with no associated fever. On examination, facial swelling, engorged jugular veins, tachypnea, and subcostal retractions were noted. Furthermore, mild language delay was observed. Chest X-ray revealed right pleural effusion, and blood tests showed mild anemia and normal albumin level. Nephrotic syndrome and superior vena cava syndrome were initially suspected, but the history and physical findings were not consistent with the diagnoses.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Images Source Type: research
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