Osmokinetics: A new dynamic concept in dry eye disease.

CONCLUSION: A more dynamic model for osmolarity is presented in which not the value itself but the daily variation of osmolarity is identified. It is suggested that the amplitude of change in osmolarity over the course of a day or even shorter time periods could play a decisive role as a stress factor for the surface cells. The varying osmolar stress could be one of the key mechanisms leading to the cell death, inflammation, apoptosis, and goblet cell disappearance as observed in dry eye disease. Perhaps it is the mean osmolarity level at which these changes occur together with the magnitude of DVO which could identify the level of severity of dry eye disease.
PMID: 30851972 [PubMed - as supplied by publisher]

Source: Journal Francais d Ophtalmologie - March 11, 2019 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research