Could genetic engineering protect us from the deadliest animal on earth?

What if we had the technology to eliminate the threat of diseases like Zika by tweaking the biology of the mosquitoes that spread it?
Source: Health News: - Category: Consumer Health News Source Type: news

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AbstractDiagnosing a patient with Zika infection is not always straightforward. Here, we aim to describe our data collected from December 2015 to December 2017 and discuss the implemented algorithm and diagnostic challenges we encountered. At the National Reference Center for Arboviruses at the Institute of Tropical Medicine, Antwerp, Belgium (ITM), a commercial Zika virus (ZIKV) enzyme-linked immunosorbent assay (ELISA) detecting immunoglobulin (Ig) M and IgG, a commercial ZIKV immunofluorescence assay (IFA) detecting IgM, and an in-house Zika virus neutralization test (VNT) were implemented. For molecular detection of ZI...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments, Published online: 19 March 2019; doi:10.1038/s41419-019-1499-zZika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
(University of Queensland) Scientists looking at the genetics of Zika virus have found a way to fast-track research which could lead to new vaccines.The study, led by The University of Queensland and QIMR Berghofer Medical Research Institute, used a new technique to uncover Zika mutations that help foster virus replication in mosquito hosts, while hindering its ability to replicate in mammals.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
How do we … integrate pathogen reduced platelets into our hospital blood bank inventory? Transfusion. 2019 Mar 18;: Authors: Rutter S, Snyder EL Abstract For more than 50 years there has been an ongoing effort to combat transfusion-transmitted infections and provide patients with the safest possible blood. This initiative has driven much of the research within the transfusion community. Initial methods included screening donors for travel histories to banned areas and for high-risk behaviors, but pathogen-specific assays performed at the collection and manufacturing sites also have becom...
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research
In this study, we evaluated the mRNA expression of innate immune receptors (TLR3, TLR7, TLR8, TLR9, melanoma differentiation-associated protein 5/MDA-5, and reti noic acid inducible gene/RIG-1), its adapter molecules (Myeloid Differentiation Primary Response Gene 88/Myd88,Toll/IL-1 Receptor Domain-Containing Adaptor-Inducing IFN- β/TRIF), and cytokines (IL-6, IL-12, TNF-α, IFN-α, IFN-β, and IFN-γ) in the acute phase of patients infected by ZIKV using real-time PCR in peripheral blood. Patients with acute ZIKV infection had high expression of TLR3, IFN-α, IFN-β, and IFN-γ when co...
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research
What are the challenges and implications to public health presented by the rising incidence in the Americas of arboviral infections such as dengue, zika, yellow fever, and chikungunya?American Journal of Public Health
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: Public Health & Prevention Journal Article Source Type: news
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.9b02157
Source: Journal of Physical Chemistry B - Category: Chemistry Authors: Source Type: research
CONCLUSIONS Our results allowed the characterization of pregnant women exposed to ZIKV and the outcome of pregnancy.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
The new triterpene friedelan-1,3,21-trione, the known compounds friedelan-3-one, 3 β -friedelinol, 3,4-seco-friedelan-3-oic acid, 28-hydroxyfriedelan-3-one, friedelan-3-oxo-28-al, friedelan-3,21-dione, 30-hydroxyfriedelan-3-one, a mixture of 30-hydroxyfriedelan-3-one/21 α -hydroxyfriedelan-3-one, 21 β -hydroxyfriedelan-3-one, gutta-percha, squalene, and a mixture of palmitic/stearic/oleic acids were isolated from the hexane extracts of leaves and branches of T. micrantha. Their chemical structures were established by Fourier transform infrared spectroscopy (FTIR), gas chromatography (GC), 1D/2D nuclear magn...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
aacute;n Zika virus (ZIKV) is an emerging mosquito-borne member of the Flaviviridae family that has historically been known to cause sporadic outbreaks, associated with a mild febrile illness, in Africa and Southeast Asia [...]
Source: Viruses - Category: Virology Authors: Tags: Editorial Source Type: research
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