Medical News Today: Could sleep apnea be a risk factor for Alzheimer's?

A preliminary study has unearthed a potential link between sleep apnea and tau tangles, which are the neurological hallmarks of Alzheimer's disease.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news

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The objective of this study was to examine the association of objective sleep with cognitive performance in MCI patients. A subsample of 271 participants with a diagnosis of probable Alzheimer's disease (AD; N = 50) or mild cognitive impairment (MCI; N = 121) and 100 persons who were not cognitively impaired (NI) were recruited from a large population-based cohort in the island of Crete, Greece (3140 older adults aged>60 years). All participants underwent extensive neuropsychiatric/neuropsychological evaluation and a 3-day 24-hr actigraphy. Objective sleep variables and their association with ne...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
Abstract OBJECTIVES: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is used to screen for dementia in many Wisconsin Alzheimer Institute memory care clinics. After observing a pattern of lower scores for immediate memory than for delayed memory (immediate memory
Source: WMJ - Category: General Medicine Authors: Tags: WMJ Source Type: research
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
You might recall that researchers recently connected poor sleep with raised levels of tau in the brain. Sleep is needed to clear out tau, the amount of which rises during the active use of the brain while waking. Altered forms of tau protein can aggregate in the aging brain to form the neurofibrillary tangles that occur in later stages of Alzheimer's disease, and this might explain some of the known correlation between sleep disruption and neurodegeneration. The study here provides more data on this correlation, linking higher levels of tau with sleep apnea specifically, a common form of sleep disturbance. This is still a ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Alzheimer’s disease is a growing issue among Americans, but just 16% of seniors reported being regularly screened for cognitive issues, according to the Alzheimer’s Association’s new 2019 report. “There’s under-utilization of cognitive assessment in the clinical setting, and a disconnect between patient and provider over who should be initiating it,” says Joanne Pike, chief program officer at the Alzheimer’s Association. “[In] an ideal world, 100% of physicians initiate it, and 100% of seniors bring it up.” The new report finds that while the majority of doctors and sen...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Brain Source Type: news
BOSTON (CBS) — A new study from the Mayo Clinic finds that people with sleep apnea may have higher accumulations of a toxic protein associated with Alzheimer’s disease in their brains. People with obstructive sleep apnea stop breathing periodically while sleeping which can cause a variety of health issues. Researchers looked at 288 people over 65 without dementia. Those whose bed partners said they stopped breathing while sleeping had a 4 1/2 percent higher level of tau in their brains than people without witnessed sleep apnea. Tau is a protein that clumps in the brains of people with Alzheimer’s which co...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local Alzheimer’s Dr. Mallika Marshall Local TV Sleep Apnea Source Type: news
By Sandee LaMotte, CNN (CNN) — Here’s another reason why getting a good night’s sleep should be on your must-do list: Sleeping fewer than six hours a night or waking frequently raises your risk of developing damaging plaque in arteries throughout your body, not just your heart. Previous research has shown poor sleep to be strongly associated with coronary heart disease, but “This is the first study to show that objectively measured sleep is independently associated with atherosclerosis throughout the body,” José Ordovás, director of nutrition and genomics at the Jean Mayer USDA H...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health CNN Heart Disease Sleep Tufts University Source Type: news
Conclusions:Uvulopalatopharyngoplasty may have a preventive effect on dementia in patients with OSA.Citation:Cho JH, Suh JD, Han KD, Jung JH, Lee HM. Uvulopalatopharyngoplasty may reduce the incidence of dementia caused by obstructive sleep apnea: National Insurance Service Survey 2007–2014.J Clin Sleep Med. 2018;14(10):1749–1755.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
We present how new discoveries from animal models, human sleep experiments, and Alzheimer's disease biomarkers point to an active role of disturbed sleep in dementia pathogenesis. We show preliminary data on how sex, genetics, physical exercise and cognitive reserve can strengthen or weaken the association between obstructive sleep apnea and dementia. We present preliminary results of obstructive sleep apnea treatment, which can slow, stop or reverse neurodegenerative processes accentuated by obstructive sleep apnea, even in individuals already affected by a neurodegenerative disease. We propose future research directions ...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Conclusion: This meta-analysis confirmed the association between sleep and cognitive impairment or AD and, for the first time, consolidated the evidence to provide an “average” magnitude of effect. As sleep problems are of a growing concern in the population, these findings are of interest for potential prevention of AD. The Study in Context: Bill Gates announces $50 million investment to fight Alzheimer’s Disease From Anti-Alzheimer’s ‘Magic Bullets’ to True Brain Health 10 million people develop dementia every year Report: 35% of worldwide dementia cases could be prevented by modifyi...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Alzheimer’s Disease cognitive problems cognitive-decline dementia sleep sleep apnea sleep disorders sleep parameters sleep problems Source Type: blogs
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