Preparation of cubic-shaped sorafenib-loaded nanocomposite using well-defined poly(vinyl alcohol alt-propenylene) copolymer

Publication date: Available online 10 March 2019Source: International Journal of PharmaceuticsAuthor(s): Tivadar Feczkó, Gabriella Merza, György Babos, Bernadett Varga, Eszter Gyetvai, László Trif, Ervin Kovács, Robert TubaAbstractVinyl alcohol (VA) copolymers having fine tunable polarities are emerging materials in drug delivery applications. VA copolymers rendering well-defined molecular architecture (C/OH ratio = 2, 4, 5 and 8) were used as carriers for model drug compound, fluorescein exhibited significantly different release characteristics depending on the polarity of the polymers. Based on the preliminary drug release tests the well-defined VA copolymer having C/OH = 5 ratio, poly(vinyl alcohol alt-propenylene) copolymer (PVA-5) was selected for nanocomposite synthesis. Sorafenib anticancer drug was embedded into PVA-5 (C/OH = 5 ratio) nanoparticles by nanoprecipitation resulting in nanoparticles exhibiting unusual cubic shape. The sorafenib-loaded nanocomposites showed continous release during a day and concentration-dependant cytotoxicity on HT-29 cancer cells. This might be interpreted by the sustained release of the drug.Graphical abstractSorafenib chemotherapeutic drug VA-copolymer (C/OH = 5 ratio) nanocomposite exhibiting unusual cubic shape shows prolonged active agent release.
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research