LPA1 receptor activation induces PKC α nuclear translocation in Glioblastoma cells.

In this study, we aimed to determine if a classical PKC (α isozyme), could be activated through LPA1 in GBM cell lines and if this activation impacts on cell number. We found that LPA1 induces PKCα translocation to the nucleus, but not to the cell membrane after LPA treatment and the cell number diminished when LPA1/PKCα signaling was blocked, suggesting a relevant role of LPA1 and PKCα in GBM growth.
PMID: 30849522 [PubMed - as supplied by publisher]

Source: The International Journal of Biochemistry and Cell Biology - March 4, 2019 Category: Biochemistry Authors: Valdés-Rives SA, de la Fuente-Granada M, Velasco-Velázquez MA, González-Flores O, González-Arenas A Tags: Int J Biochem Cell Biol Source Type: research