Parasitic plasmid-host dynamics and host competition in flowing habitats.

Parasitic plasmid-host dynamics and host competition in flowing habitats. Math Biosci. 2019 Mar 05;: Authors: Grover JP, Wang FB Abstract Competition and coexistence were examined for two bacterial species, each potentially carrying a fitness-reducing, parasitic plasmid that was vertically transmitted with possible loss through segregation. Here, the fitness reduction of hosts was due to a toxin produced by plasmid-bearing cells and inhibiting plasmid-free cells. These populations were placed in a flow reactor habitat representing an idealized mammal gut. It was numerically shown that parasitic plasmids can mediate coexistence of competing host species, in conditions where plasmid-free hosts could not coexist. Numerical construction of a coexistence example suggests that it arises only for a narrow parameter range. In particular, both rates of segregation and the growth costs of plasmid carriage must be relatively low. PMID: 30849409 [PubMed - as supplied by publisher]
Source: Mathematical Biosciences - Category: Statistics Authors: Tags: Math Biosci Source Type: research