Efficacy of a new topical formulation of selamectin plus sarolaner for the control of fleas and ticks infesting cats in Japan

Publication date: Available online 8 March 2019Source: Veterinary ParasitologyAuthor(s): Wakako Yonetake, Takeshi Fujii, Masaya Naito, Andrew Hodge, Steven Maeder, Douglas RuggAbstractThe efficacy of a single application of a new topical formulation containing selamectin plus sarolaner (Revolution® Plus / Stronghold® Plus, Zoetis) was evaluated against fleas and ticks infesting cats enrolled as veterinary patients in two field studies conducted in Japan and against Haemaphysalis longicornis ticks on cats in a laboratory study.In the laboratory study, sixteen cats were ranked based on pre-treatment tick counts and allocated randomly to treatment on Day 0 with either selamectin plus sarolaner or placebo. Cats were infested with adult H. longicornis on Days -2, 5, 12, 19, 26 and 33. Efficacy relative to placebo was based on live attached tick counts conducted 48 hours after treatment and subsequent re-infestations. Selamectin plus sarolaner reduced live, attached H. longicornis counts by 96.4% within 48 hours of treatment, and by ≥91.7% within 48 hours of weekly re-infestation for 35 days, based on arithmetic means.In the field studies, 67 client-owned cats harboring 6 or more live fleas and 63 cats harboring four or more live attached ticks were enrolled to evaluate selamectin plus sarolaner for efficacy and safety compared with a registered product. Cats were allocated randomly to treatment with selamectin plus sarolaner or fipronil plus (S)-methoprene based on order...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research